Locomotor-Reducing Effects and Structural Characteristics of Inhaled Zerumbone and Tetrahydrozerumbone Derivatives
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概要
- 論文の詳細を見る
Zerumbone 1 is an 11-membered cyclic sesquiterpene obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the structure–activity relationship of 1, α-humulene (2), tetrahydrozerumbone stereoisomers (3–5), and tetrahydrozerumbone derivatives (6–9). The oxygen-containing functional groups and the configurations at C1 and C2 contributed to the spontaneous locomotor activity reduction of zerumbone 1 and derivatives 2–9.
- 公益社団法人 日本薬学会の論文
著者
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Ito Michiho
Department Of Pharmacognosy Graduate School Of Pharmaceutical Science Kyoto University
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Miyoshi Takashi
Department 4 Technology Research Division 2 Honda R&d Co. Ltd. Automobile R&d Center
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Kitayama Takashi
Department Of Advanced Bioscience Graduate School Of Agriculture Kinki University
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Kitayama Takashi
Department of Advanced Bioscience, Graduate School of Agriculture, Kinki University
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Ogawa Kakuyou
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University
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