Carbohydrate-Dependent Hemolytic Activity of the Conjugate Composed of a C-Type Lectin, CEL-I, and an Amphiphilic α-Helical Peptide, 4_3-βAla_2
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概要
- 論文の詳細を見る
A lectin-cationic peptide conjugate, 4_3-CEL-I, was prepared from an invertebrate C-type lectin, CEL-I, and an amphiphilic α-helical peptide, 4_3-βAla_2,[Ac-(Leu-Ala-Arg-Leu)_3-βAla_2]. When 4_3-CEL-I was incubated with rabbit erythrocytes, hemolysis was observed, especially at basic pH. Inhibition experiment using some carbohydrates suggested that hemolytic activity of 4_3-CEL-I was caused by the interaction between 4_3-βAla_2 portion in the conjugate and the lipid bilayer after binding to the carbohydrate chains on the cell surface by the lectin activity of CEL-I.
- 社団法人日本農芸化学会の論文
- 1999-07-23
著者
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HATAKEYAMA Tomomitsu
Department of Applied Chemistry, Faculty of Engineering, Nagasaki University
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Hatakeyama T
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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Hatakeyama Tomomitsu
Laboratory Of Biochemistry Faculty Of Agriculture Kyushu University:(present Address)dept. Of Applie
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Aoyagi H
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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NIIDOME Takuro
Department of Applied Chemistry, Faculty of Engineering, Nagasaki University
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AOYAGI Haruhiko
Department of Applied Chemistry, Faculty of Engineering, Nagasaki University
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新留 琢郎
長崎大学 院 生産科学
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Tomomitsu Hatakeyama
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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Kodama H
Department Of Chemistry Faculty Of Science And Engineering Saga University
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Kuwahara H
Department Of Chemistry Faculty Of Science And Engineering Saga University
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Kodama Hiroaki
東京理科大学 薬学部分子病態学
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KUWAHARA Hiromiki
Department of Applied Chemistry, Faculty of Engineering, Nagasaki University
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KAMINE Tetsuji
Department of Applied Chemistry, Faculty of Engineering, Nagasaki University
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KONISHI Yuko
Department of Applied Chemistry, Faculty of Engineering, Nagasaki University
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Konishi Yuko
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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Kamine Tetsuji
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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Hatakeyama Tomomitsu
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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Aoyagi Haruhiko
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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Aoyagi Haruhiko
Faculty Of Pharmaceutical Science:faculty Of Science:kyushu University
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Niidome Takuro
Department Of Applied Chemistry Faculty Of Engineering And Center For Future Chemistry Kyushu Univer
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Konishi Y
Kirin Brewery Co. Ltd. Gunma Jpn
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Niidome Takuro
Department of Applied Chemistry and Biochemistry, Graduate School of Science and Technology
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