The Presence of Tumor Necrosis Factor-α and its Antibody in the Sera of Cachexic Patients with Gastrointestinal Cancer

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概要

• 論文の詳細を見る

• Although cancer cachexia has been shown to involve several cytokines, the tumor necrosis factor-α (TNF) has rarely been detected in such patients. In this study, sera from 21 patients with cancer cachexia were examined for the presence of TNF and the anti-TNF antibody using an enzymelinked immunosorbent assay (ELISA) and Western blotting, respectively. All of the patients had recurrent cancer and manifested the characteristics of progressive body weight loss. TNF was found in the sera of four patients (20%) at levels ranging from 10.4 to 53.1 pg/ml, while a positive reaction for the anti-TNF antibody was detected in the sera from six patients (30%), two of whom showed both TNF and its antibody. Thus, either TNF or the anti-TNF antibody was present in the sera from 8 of 21 patients (40%). The results of this study indicate that TNF may be present in the circulation of at least 40% of cachexic patients, and suggest that it may be one of the main mediators of cancer-associated cachexia.

• 日本医科大学の論文
• 1995-03-25

著者

• Onda Masahiko

  First Department of Surgery, Nippon Medical School

• MATSUKURA Norio

  First Department of Surgery, Nippon Medical School

• TOKUNAGA AKIRA

  First Department of Surgery, Nippon Medical School

• Ohkuni Hisashi

  Division Of Immunology Institute Of Gerontology Nippon Medical School

• Ohkuni Hisashi

  Division Of Immunology The Institute Of Gerontology Nippon Medical School

• Tokunaga Akira

  日本医科大学武蔵小杉病院 消化器病センター

• Matsukura Norio

  Surgery For Organ Function And Biological Regulation First Department Of Surgery Nippon Medical Scho

• Matsukura Norio

  First Department Of Surgery Nippon Medical School

• Tokunaga Akira

  Post-marketing Development Research Center Fujisawa Pharmaceutical Co. Ltd.

• Okuda Takeshi

  Surgery For Organ Function And Biological Regulation (department Of Surgery I) Nippon Medical School

• Onda Masahiko

  The First Department Of Surgery Nippon Medical School Japan

• Onda Masahiko

  First Department Of Surgery Nippon Medical School

• Todome Yuko

  Division Of Immunology Institute Of Gerontology Nippon Medical School

• Todome Yuko

  Division Of Immunology The Institute Of Gerontology Nippon Medical School

• Tokunaga Akira

  First Department Of Surgery Nippon Medical School

• KIYAMA TERUO

  First Department of Surgery, Nippon Medical School

• FUJITA ITSUO

  First Department of Surgery, Nippon Medical School

• OKUDA TAKESHI

  First Department of Surgery, Nippon Medical School

• MIZUTANI TAKASHI

  First Department of Surgery, Nippon Medical School

• Kiyama Teruo

  Surgery For Organ Function And Biological Regulation (department Of Surgery I) Nippon Medical School

• Fujita Itsuo

  Surgery For Organ Function And Biological Regulation (department Of Surgery I) Nippon Medical School

• Kiyama Teruo

  Department Of Surgery I Nippon Medical School

• Mizutani Takashi

  First Department Of Surgery Nippon Medical School

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