Immunopathological Activities of Extracellular Products of Streptococcus mitis, Particularly a Superantigenic Fraction

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概要

• 論文の詳細を見る

• Previously, we prepared extracellular products, fractions F-1 and F-2 of Streptococcus mitis 108,an isolate from the tooth surface of an infant, and showed that F-1 exhibited inflammatory cytokine-inducing activities. In the present study, we present evidence that fraction F-2 induced human T-cell proliferation in the presence of irradiated human peripheral blood mononuclear cells and selectively activated T cells bearing Vβ2 and Vβ5.1 in the T-cell receptor. F-1,on the other hand, stimulated human gingival fibroblasts to support the T-cell proliferation in the same way as human gamma interferon or Prevotella intermedia lipopolysaccharide (LPS). Fraction F-1 also primed gingival fibroblasts to support the production of interleukin-2 and gamma interferon by the T cells upon stimulation with F-2. Human gingival fibroblasts stimulated with fraction F-1,like those stimulated by P. intermedia LPS and human gamma interferon, exhibited human leukocyte antigen (HLA)-DR mRNA expression and cell surface HLA-DR molecules as detected by enzyme-linked immunosorbent assay. An anti-HLA-DR monoclonal antibody inhibited T-cell proliferation in response to F-2,probably through inactivating the accessory function of HLA-DR-bearing fibroblasts. T cells activated with F-2 in the presence of irradiated peripheral blood mononuclear cells exhibited definite cytotoxic effects against fibroblasts and squamous carcinoma cells originating from human oral tissues. These findings are strongly suggestive of an association of extracellular products of viridans streptococci with pathogenesis of oral mucosal diseases, particularly those disorders in gingiva which are accompanied by heavy infiltration of T cells.

• 日本医科大学の論文
• 1996-03-25

著者

• MATSUSHITA Kenji

  Department of Ophthalmology, Osaka University Medical School

• Fujimaki Wakae

  東京女子医科大学 微生物免疫

• Fujimaki Wakae

  Department Of Microbiology And Immunologu Tokyo Women's Medical College

• UCHIYAMA Takehiko

  Department of Microbiology and Immunology, Tokyo Women's Medical College

• KATO Hidehito

  Department of Microbiology Tokyo Women's Medical College

• Kato H

  Department Of Microbiology And Immunology School Of Medicine Tokyo Women's Medical University

• Uchiyama T

  Univ. Tokushima Tokushima Jpn

• Uchiyama Takehiko

  Department Of Microbiology And Immunology Tokyo Women's Medical University School Of Medicine

• Matsushita Kenji

  Department Of Electrical Engineering Faculty Of Engineering Osaka City University

• Ohkuni Hisashi

  Division Of Immunology Institute Of Gerontology Nippon Medical School

• TAKADA Haruhiko

  Department of Microbiology and Immunology, Tohoku University School of Dentistry

• KOTANI Shozo

  Osaka College of Medical Technology

• NAGAOKA Shigetaka

  Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Media

• IGARASHI HIDEO

  Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health

• KAWAGOE MASATAKA

  Department of Operative Dentistry and Endodontology, Kagoshima University Dental School

• Uchiyama Takehiko

  Department Of Microbiology Tokyo Women's Medical College

• Matsushita Kenji

  Department Of Microbiology And Immunology And Department Of Operative Dentistry And Endodontology Ka

• Uchiyama Takehiko

  Department Of Microbiology And Immunology School Of Medicine Tokyo Women's Medical University

• Igarashi Hideo

  Department Of Agricultural Chemistry Yamagata University

• Takada Haruhiko

  Department Of Mechanical Engineering Faculty Of Engineering Shinshu University

• Nagaoka Shigetaka

  Department Of Operative Dentistry And Endodontology Kagoshima University Dental School

• Kawagoe Masataka

  Department Of Operative Dentistry And Endodontology Kagoshima University Dental School

• Uchiyama Takehiko

  Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University

• Kato Hidehito

  Department Of Immunology Tokyo Women's Medical University

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