Design of Controlled Release System with Multi-layers of Powder
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概要
- 論文の詳細を見る
Pellets containing active ingredients were coated with water-insoluble powders, i.e. hydrogenated caster oil (Lubliwax (WAX)) and magnesium stearate (Mg-St). The influences of the structural difference of the sustained release layer and curing conditions on the drug release rate were investigated. Sodium valproate (VP-Na) was used as a highly water-soluble model drug. Drug release profiles were influenced by the combination of the WAX layer and the Mg-St layer. Even if the formula of sustained release layers were the same, drug release rate could be affected by the structural difference of the controlled release layer. The Mg-St layer was more effective in prolonging drug release than the WAX layer. Compared with single and double layer types, the triple layer (sandwich) type was most effective in obtaining a long sustained drug release. Heat-treatment retarded drug release mainly by increasing the density of the sustained release layer of the WAX. The Mg-St was effective in protecting the agglomeration between particles during heat-treatment. Optimal heat-treatment conditions were found to exist. Scanning electron microscopy (SEM) analysis indicated that heat-treatment caused the WAX to melt, formed a film-like structure and made the release layer dense. Furthermore, heat-treatment changed the release pattern of VP-Na from sustained release pellets with a multi-layer of powder, leading to zero-order release.
- 公益社団法人日本薬学会の論文
- 2002-09-01
著者
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Ueda Masumi
Administration Croup Dainippon Pharmaceutical Co. Lid.
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中村 康彦
Department Of Formulation Research Dainippon Pharmaceutical Co. Ltd.
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SHIMONO Norihito
Formulation Group, Dainippon Pharmaceutical Co., Ltd.
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NAKAMURA Yasuhiko
Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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Nakamura Yoshihide
Technical Department Fuji Chemical Industries Co. Ltd.
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Nakamura Y
Tohoku Pharmaceutical Univ. Sendai Jpn
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Shimono N
Formulation Group Dainippon Pharmaceutical Co. Ltd.
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Ueda M
Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Nakamura Y
Department Of Pharmacognosy Tohoku Pharmaceutical University
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Nakamura Yasuhiko
Pharmaceutical Research Dainippon Pharmaceutical Co. Ltd.
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