Immune Recovery Effects of Immunopotentiator from Pantoea agglomerans 1 (IP-PA1) on Low Antibody Productions in Response to Salmonella Enteritidis Vaccine and Sheep Red Blood Cells in Dexamethasone-Treated Stressed Chicken Models
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概要
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Considering the usefulness of the immunopotentiator from Pantoea agglomerans 1 (IP-PA1), which is a purified lipopolysaccharide (LPS) derived from symbiotic gram-negative bacteria of food crops, in controlling immunosuppression in poultry husbandry, in this study, we examined its immune-recovery effects in dexamethasone-treated stressed chicken models. Three-week-old chickens daily administered 10 μg/kg of dexamethasone for 35 days to induce stress showed more whole body weight loss; relative thymic, bursal, and splenic weight losses; and decrease in the number of peripheral blood lymphocytes, as compared with the control chickens on day 35; the IP-PA1-pretreated, dexamethasone-treated chickens showed reduced weight losses. Five- to eight-week-old chickens administered 5 mg/kg of dexamethasone showed excessive apoptosis of thymic and bursal lymphocytes 24 hr after a single dexamethasone treatment; apoptosis was inhibited in the IP-PA1-pretreated, dexamethasone-treated chickens. Chickens daily administered 10 μg/kg of dexamethasone for 35 days and injected with commercial Salmonella Enteritidis (SE) vaccine or sheep red blood cells (SRBC) on days 7 and 21 showed about 8- or 2-fold lower antibody production in response to SE or SRBC, respectively, as compared with the control chickens on day 35; the antibody production in response to SE or SRBC was increased in the IP-PA1-pretreated, dexamethasone-treated chickens. These results indicate that IP-PA1 exerts inhibitory effects on dexamethasone-induced immunosuppression and that it may be useful in controlling immunosuppression in poultry husbandry.
- 社団法人 日本獣医学会の論文
著者
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Taya Kazuyoshi
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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林 良博
東京大学
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林 良博
東京大学農学部
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Hayashi Y
Hadepartment Of Environmental Technology And Urban Planning Nagoya Institute Of Technology
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SOMA Gen-Ichiro
Institute for Health Sciences, Tokushima Bunri University
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HAYASHI Yoshihiro
Laboratory of Global Animal Resource Science, Graduate School of Agricultural and Life Sciences, The
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MATSUMOTO Yasunobu
Laboratory of Global Animal Resource Science, Graduate School of Agricultural and Life Sciences, The
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Watanabe Gen
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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HAYASHI Yoshihiro
Graduate School of Agriculture and Life Sciences, The University of Tokyo
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Soma Gen-ichiro
Institute For Health And Sciences Tokushima Bunri University
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Soma Gen-ichiro
Institute For Health Sciences Tokushima Bunri University
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Kohchi Chie
Institute For Health And Sciences Tokushima Bunri University
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Hirota Yoshikazu
Laboratory Of Aminal Microbiology College Of Agriculture
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HEBISHIMA Takehisa
Laboratories of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, To
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Matsumoto Yasunobu
Lab. Of Global Animal Resource Sci. Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo
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Hebishima Takehisa
The United Graduated School Of Veterinary Sciences Gifu Univ.
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Hayashi Yoshihiro
Laboratory Of Global Animal Resource Science Graduate School Of Agricultural And Life Sciences Unive
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Matsumoto Yasunobu
Laboratory Of Global Animal Resource Science Graduate School Of Agricultural And Life Sciences Unive
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Hebishima Takehisa
Laboratory Of Veterinary Physiology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo U
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Watanabe Gen
Laboratories Of Veterinary Physiology Dep. Of Veterinary Medicine Fac. Of Agriculture Tokyo Univ. Of
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林 良博
東京大学大学院農学生命科学研究科 国際動物資源科学研究室
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HAYASHI Yoshihiro
Department of Veterinary Anatomy, Faculty of Agriculture, The University of Tokyo
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HAYASHI Yoshihiro
Department of Veterinary Anatomy, Faculty of Agriculture,The University of Tokyo
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HEBISHIMA Takehisa
Laboratory of Veterinary Physiology Division of Animal Life Science, Institute of Symbiotic Science and Technology, Graduate School, Tokyo University of Agriculture and Technology
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