ANALYSIS OF THE EFFECT OF AN ANTI-INFLAMMATORY STEROID, DEXAMETHASONE, ON NEUTROPHIL CHEMOTAXIS IN THE BOYDEN CHAMBER WITH A MODIFIED ^<51>Cr-LABELING METHOD
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概要
- 論文の詳細を見る
For the determination of leukocyte chemotaxis in the Boyden chamber toward zymosan-activated serum, a modification of the ^<51>Cr-labeling method originally introduced by Gallin et al. was made using a polycarbonate filter at the top of a double filter system. By application of this method, it was demonstrated that an anti-inflammatory steroid, dexamethasone at relatively low doses, directly inhibited chemotactic movement of leukocytes after the pretreatment of the cells with dexamethasone for several hours. This inhibitory effect was proved to be a common property of glucocorticoids. The leukocyte-inhibitory effect manifested within the cell body and the release of any extracellular factors mediating the inhibitory effect of the corticoid into the medium was not demonstrated. The present data suggests that the inhinbitory effect of dexamethasone on leukocyte infiltration observed in vivo is attributed to the direct inhibitory effect of dexamethasone on the motility of leukocytes.
- 公益社団法人日本薬学会の論文
著者
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Kurihara Atsushi
Department Of Electrical Engineering Faculty Of Engineering Kanagawa University
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Kurihara Atsushi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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TSURUFUJI SUSUMU
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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Tsurufuji Susumu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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OJIMA FUMIYOSHI
Department of Pharmacy, Yamagata University Hospital
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Ojima F
Yamagata Univ. Hospital Jpn
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Ojima Fumiyoshi
Department Of Pharmacy Yamagata University Hospital
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OJIMA FUMIYOSHI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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