A Novel A-Kinase Anchoring Protein in the Heart Interacts with G .ALPHA. 13.
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概要
- 論文の詳細を見る
A cDNA of a tentative A-kinase anchoring protein, presumably coupled with heterotrimeric GTP binding protein α 13 subunit (G α 13), was cloned from a human heart cDNA library. It was approximately 650 bases and its mRNA was expressed in the heart. Homology search of DNA sequences revealed that it was a novel cDNA with 84% homology with the partial sequence of rabbit cDNA of AKAP 120 without a stop codon. 3'-Rapid Amplification of cDNA Ends (3'-RACE) and yeast functional assay were performed to determine the 3'-end of the cDNA and ribosomal frameshifting was suggested as a translational mechanism. Here we report that a protein encoded by the cDNA may be involved in intracellular signal transduction via the G α 13 and PKA in hearts.
- International Heart Journal刊行会の論文
著者
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Suzuki Miwako
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Tonoki Hidefumi
Division Of Cell Biology Cancer Institute Hokkaido University School Of Medicine
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Kitabatake Akira
Department Of Cardicvascular Medicine Hokkaidou University
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KAWAGUCHI Hideaki
Division of Cardiovascular Medicine, Hokkaido Univ., School of Medicine.
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Murakami Takeshi
Division Of Accelerator Physics And Engineering Institute Of Radiological Sciences
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FURUUCHI Keiji
Division of Cell Biology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
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OZAKI Takefumi
Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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IIZUKA Kenji
Division of Cardiovascular Medicine, Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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KAWAGUCHI Hideaki
Division of Cardiovascular Medicine, Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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KITABATAKE Akira
Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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SUZUKI Miwako
Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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MURAKAMI Takeshi
Division of Cardiovascular Medicine, Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo, Japan
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- A Novel A-Kinase Anchoring Protein in the Heart Interacts with G .ALPHA. 13.