壊死性髄膜脳炎の7頭の犬における組み合わせ治療(サイクロスポリン+プレドニゾロン)とプレドニゾロン単一治療の比較(内科学)
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概要
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犬における壊死性髄膜炎(NME)において従来からの第一治療法はグルココルチコイドの免疫抑制量の投与である.しかし,反応は様々で臨床徴候は漸減投与で時々急激に再発することがある.予後は不良で長期の治療では多くの合併症の原因になる.この研究において,NMEの犬において組み合わせ治療(サイクロスポリン+プレドニゾロン)とプレドニゾロン単一治療の長期の効果を比較した.この研究のすべてのNME症例は磁気共鳴映像および脳脊髄液分析を行い,病理組織学検査によって確定した.組み合わせ治療群の平均生存日数は305.7±94.7日であった.単一プレドニゾロン治療群の平均生存日数は58.3±30.5日であった.NME症例においてサイクロスポリンとプレドニゾロンの組み合わせ治療はプレドニゾロンのみの投与より生存日数でより効果的であったことをこの報告は示唆している.
- 2007-12-25
著者
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Kim J.-h.
韓国
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Park H.-m.
韓国
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JUNG Dong-In
Departments of Veterinary Internal Medicine
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KANG Byeong-Teck
Departments of Veterinary Internal Medicine
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PARK Chul
Departments of Veterinary Internal Medicine
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YOO Jong-Hyun
BK21 Program of Integrative Network Systems for Veterinarians in Basic Science, Industrial Animals a
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GU Su-Hyun
Departments of Veterinary Internal Medicine
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JEON Hyo-Won
Departments of Veterinary Internal Medicine
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KIM Ju-Won
Departments of Veterinary Internal Medicine
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HEO Ra-Young
Departments of Veterinary Internal Medicine
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SUNG Hyun-Jeong
Departments of Veterinary Internal Medicine
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EOM Ki-Dong
Veterinary Diagnostic Imaging, College of Veterinary Medicine, Konkuk University
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LEE Jong-Hwan
Veterinary Anatomy, College of Veterinary Medicine, Konkuk University
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WOO Eung-Je
College of Electronics and Information, Kyunghee University
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PARK Hee-Myung
Departments of Veterinary Internal Medicine
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Gu Su‐hyun
Konkuk Univ. Seoul
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Gu Su-hyun
韓国
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Jeon Hyo-won
Department Of Veterinary Internal Medicine College Of Veterinary Medicine Konkuk University
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Yoo Jong-hyun
Departments Of Veterinary Internal Medicine College Of Veterinary Medicine Seoul National University
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Yoo Jong-hyun
韓国
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Kim Ju-won
Department Of Veterinary Internal Medicine College Of Veterinary Medicine Konkuk University
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Jang Dong‐pyo
Gachon Univ. Medicine And Sci. Incheon
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Park Hee‐myung
Konkuk Univ. Seoul
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Park Hee-myung
Departments Of Theriogenology College Of Veterinary Medicine Konkuk University
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Park Hee-myung
Bk21 Program Of Basic And Diagnostic Veterinary Specialist Program For Animal Diseases And Departmen
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Park Hee-myung
韓国
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Lee Jong-hwan
Veterinary Anatomy College Of Veterinary Medicine Konkuk University
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Eom Ki-dong
Departments Of Veterinary Internal Medicine College Of Veterinary Medicine Konkuk University
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Kim J.-h.
National Veterinary Research And Quarantine Service
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Park T.
Department Of Internal Medicine And Infectious Disease College Of Veternary Medicine Seoul National
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Park Hee-myung
Department Of Internal Medicine And Infectious Disease College Of Veterinary Medicine Seoul National
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Kim J‐y
Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido Jpn
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Woo Eung‐je
Kyung Hee Univ. Gyeonggi‐do Kor
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Kim Jin-hyun
Department Of Veterinary Pathology College Of Veterinary Medicine Seoul National University And Scho
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Kim Jin-hyun
Department Of Veterinary Pathology College Of Veterinary Medicine And Agricultural Biotechnology Seo
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Park Chul
Department Of Fisheries And Aquatic Sciences University Of Florida
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Kim Ju-won
Department Of Mechanical Engineering Graduate School Of Korea University
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Park Chul
Department Of Crop Science And Biotechnology Chonbuk National University
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JUNG Dong-In
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Gyeongsang National University
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Kang Byeong-Teck
Department of Veterinary Internal Medicine, Konkuk University
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PARK Chul
Department of Crop Science & Biotechnology, Chonbuk University
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