Melanogenesis Inhibition by an Oolong Tea Extract in B16 Mouse Melanoma Cells and UV-Induced Skin Pigmentation in Brownish Guinea Pigs

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概要

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• To investigate the new physiological functions of oolong tea, the effects on melanogenesis were studied. An oolong tea extract inhibited melanogenesis without affecting cell growth in B16 mouse melanoma cells. However, the oolong tea extract hardly showed any inhibitory effect on mushroom tyrosinase in a cell-free system. The effects of an oolong tea extract on the intracellular tyrosinase level in B16 cells were therefore studied. All the levels of activity, protein and mRNA were decreased in the oolong tea extract-treated cells. We also investigated the inhibitory effects of oolong tea on the pigmentation induced by ultraviolet B (UVB) by using brownish guinea pigs in vivo. The number of 3,4-dihydroxyphenylalanine (DOPA)-positive melanocytes increased by UVB was repressed by an oral administration of oolong tea. These results imply that oolong tea might be effective in whitening and that its inhibitory effect on melanogenesis was involved in the decrease of intracellular tyrosinase at the mRNA level.

• 社団法人 日本農芸化学会の論文
• 2007-08-23

著者

• Fujiwara-hatano Yoko

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Abe Hiroko

  Department Of Medicine Metabolism And Endocrinology Juntendo University School Of Medicine

• Fujiwara Yoko

  Graduate School Of Humanities And Sciences Ochanomizu Univ.

• Abe Hiroko

  Department Of Nutrition And Food Science Ochanomizu University

• Fujiwara Yoko

  Department Of Food Science And Nutrition Ochanomizu University

• AOKI Yumi

  Department of Nutrition and Food Science, Ochanomizu University

• TANIGAWA Tomoko

  Department of Nutrition and Food Science, Ochanomizu University

• Aoki Yumi

  Department Of Nutrition And Food Science Ochanomizu University

• Tanigawa Tomoko

  Department Of Nutrition And Food Science Ochanomizu University

• Abe Hiroko

  Department Of Medicine Metabolism And Endocrinology Juntendo University Graduate School Of Medicine

• Fujiwara Yoko

  Department Of Food And Nutritional Science Graduate School Of Humanities And Sciences Ochanomizu University

• FUJIWARA Yoko

  Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University

• FUJIWARA Yoko

  Department of Nutrition and Food Science, Ochanomizu University

• Fujiwara Yoko

  Department of Food and Nutrition, Ochanomizu University

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