The Metabolism and Distribution of Docosapentaenoic Acid (n-6) in the Liver and Testis of Growing Rats
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概要
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To investigate the metabolism and distribution of docosapentaenoic acid (22:5n-6, DPA) in the liver and testis of growing rats, 22:5n-6 was administered to their dams. Newborn rats with a low hepatic arachidonic acid (20:4n-6, AA) level were generated by administrating a diet rich in docosahexaenoic acid (22:6n-3, DHA) but n-6 fatty acid (FA) free to pregnant dams. After parturition, 22:5n-6 or linoleic acid (18:2n-6, LA) was administered with a high level of 22:6n-3 to the dams until weaning. At weaning, the hepatic 20:4n-6 level was significantly highest in the DPA-DHA but not LA-DHA diet-fed animals. The hepatic delta-6 desaturase (D6D) mRNA abundance was significantly lower in both the LA-DHA and DPA-DHA diet-fed animals, connoted with the 20:4n-6 content recovered by 22:5n-6 that did not involve D6D and supporting the occurrence of retroconversion in the liver of the growing rats. The low D6D level in the 3-week-old testis was not in proportion to the elevated 22:5n-6 level, implying that early testicular 22:5n-6 accumulation might require supply from the circulation system.
- 2008-10-23
著者
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Fujiwara-hatano Yoko
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Sawada Rumi
Division Of Medical Devices National Institute Of Health Sciences
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MATSUMOTO Akiyo
Department of Surgery, Tokyo Medical and Dental University School of Medicine
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FUJIWARA Yoko
Graduate School of Agriculture, Kyoto University
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Fujiwara Yoko
Graduate School Of Humanities And Sciences Ochanomizu Univ.
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Fujiwara Yoko
Graduate School Of Agriculture Kyoto University
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Cui Yan
Graduate School Of Humanities And Sciences Ochanomizu University
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Matsumoto Akiyo
Department Of Clinical Dietetics And Human Nutrition Josai University
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Fujiwara Yoko
Graduate School Of Humanities And Sciences Ochanomizu University
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Fujiwara Yoko
Department Of Food Science And Nutrition Ochanomizu University
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TAM Phyllis
Graduate School of Humanities and Sciences, Ochanomizu University
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Tam Phyllis
Dep. Of Nutrition And Food Sci. Fac. Of Human Life And Environmental Sciences Ochanomizu Univ.
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Matsumoto Akiyo
Department Of Clinical Dietetics And Human Nutrition Faculty Of Pharmaceutical Science Josai Univers
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Fujiwara Yoko
Department Of Food And Nutritional Science Graduate School Of Humanities And Sciences Ochanomizu University
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FUJIWARA Yoko
Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University
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FUJIWARA Yoko
Department of Nutrition and Food Science, Ochanomizu University
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