MUTAGENIC OR DNA-MODIFYING ACTIVITIES OF N-ALKYL-N'-NITRO-N-NITROSOGUANIDINE
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概要
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The DNA-modifying and mutagenic activities of N-alkyl homologues of MNNG were investigated by repair tests and mutation tests. All the derivatives tested (i.e., N-methyl-, N-ethyl-, N-propyl-, N-n-butyl-, N-iso-butyl-, N-pentyl- and N-hexyl-N'-nitro-N-nitrosoguanidines) showed DNA modifying and mutagenic activities. In repair test, the ethyl derivative showed the greatest activity on Xs strain. Results in repair test indicated that MNNG might produce X-ray type damage of DNA while homologue with an ethyl substituted or longer chain length might produce UV-type damage in addition to X-ray type damage of DNA.
- 日本遺伝学会の論文
著者
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NAGAO Minako
Biochemistry Div., Natl. Cancer Ctr. Res. Inst
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NAKADATE MASAHIRO
National Institute of Hygienic Sciences
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Kawachi Takashi
Biochemistry Division National Cancer Center
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YAHAGI TAKIE
Biochemistry Division, National Cancer Center Research Institute
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- MUTAGENIC OR DNA-MODIFYING ACTIVITIES OF N-ALKYL-N'-NITRO-N-NITROSOGUANIDINE