Development of Bioactive Functions in Hydrangeae Dulcis Folium. V. On the Antiallergic and Antimicrobial Principles of Hydrangeae Dulcis Folium. (2). Thunberginols C, D, and E, Thunberginol G 3'-O-Glucoside, (-)-Hydrangenol 4'-O-Glucoside, and (+)-Hydrang
スポンサーリンク
概要
- 論文の詳細を見る
Following the characterization of thunberginols A, B, and F, six bioactive principles, thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-O-glucoside, and (+)-hydrangenol 4'-O-glucoside, were isolated from Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO, together with four kaempferol and quercetin oligoglycosides. Their chemical structures have been determined on the basis of chemical and physicochemical evidence. Thunberginols C, D, E, and G and (-)-hydrangenol 4'-O-glucoside showed antiallergic activity in the in vitro bioassay using the Schultz-Dale reaction. These components also exhibited inhibitory activities on the histamine release from rat mast cells and on the histamine-induced contraction in isolated guinea pig tracheal chain. In addition, thunberginols C, D, E, and G showed antimicrobial activities against oral bacteria.
- 公益社団法人日本薬学会の論文
- 1996-08-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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MURAKAMI Nobutoshi
Kyoto Pharmaceutical University
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YAMAHARA Johji
Kyoto Pharmaceutical University
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SHIMADA Hiromi
Kyoto Pharmaceutical University
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HARADA Emiko
Research and Education Center for Genetic Information, Nara Institute of Science and Technology
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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SHIMODA Hiroshi
Kyoto Pharmaceutical University
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村上 啓寿
阪大院薬:presto
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Yamahara J
Kyoto Pharmaceutical University
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Miki Akiko
Kyoto Pharmaceutical University
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HARADA Emiko
Kyoto Pharmaceutical University
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NAITOH Yoshikazu
Kyoto Pharmaceutical University
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Harada E
Research And Education Center For Genetic Information Nara Institute Of Science And Technology
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Naitoh Y
Kyoto Pharmaceutical University
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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