Development of Bioactive Functions in Hydrangeae Dulcis Folium. VI.Syntheses of Thunberginols A and F and Their 3'-Deoxy-Derivatives Using Regiospecific Lactonization of Stilbene Carboxylic Acid : Structures and Inhibitory Activity on Histamine Release of
スポンサーリンク
概要
- 論文の詳細を見る
Lactonization reaction of 2-carboxystilbene mediated by copper(II) chloride proceeded regiospecifically to give the five-membered lactone, while the bromolactonizations using N-bromosuccinimide and anodic oxidation were found to furnish the six-membered lactone. Using these regiospecific lactonization reactions as a key step, antiallergic and antimicrobial isocoumarins and the benzylidenephthalides thunberginols A and F and their 3'-deoxyanalogs were synthesized from phyllodulcin and hydrangenol.Two phthalides called hydramacrophyllols A and B were isolated from Hydrangeae Dulcis Folium and their stereostructures were determined on the basis of physicochemical and chemical evidence, which included the syntheses of hydramacrophyllols A and B from hydrangenol by the application of the lactonization method using copper(II)chloride. In addition, hydramacrophyllols A and B were found to exhibit an inhibitory effect on the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction.
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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MURAKAMI Nobutoshi
Kyoto Pharmaceutical University
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YAMAHARA Johji
Kyoto Pharmaceutical University
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SHIMADA Hiromi
Kyoto Pharmaceutical University
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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矢木 信博
京都薬科大学生薬学教室
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SHIMODA Hiroshi
Kyoto Pharmaceutical University
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村上 啓寿
阪大院薬:presto
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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矢木 信博
Kyoto Pharmaceutical University
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Yamahara J
Kyoto Pharmaceutical University
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YAGI Nobuhiro
Kyoto Pharmaceutical University
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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