POTENT IMMUNOSUPPRESSIVE PRINCIPLES, DIMERIC SESQUITERPENE THIOALKALOIDS, ISOLATED FROM NUPHARIS RHIZOMA, THE RHIZOMA OF NUPHAR PUMILUM (NYMPHAEACEAE) : STRUCTURE-REQUIREMENT OF NUPHAR-ALKALOID FOR IMMUNOSUPPRESSIVE ACTIVITY
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概要
- 論文の詳細を見る
Potent immunosuppressants, the dimeric sesquiterpene thioalkaloids, 6-hydroxythiobinupharidine (2), 6,6'-dihydroxythiobinupharidine (3), 6-hydroxythionuphlutine B (5) and 6'-hydroxythionuphlutine B (6), were isolated from a natural medicine, Nupharis Rhizoma, the rhizoma of Nuphar pumilum (TIMM.) DC., through bioassay-guided separation together with five quinolizidine alkaloids (8,9,10,11,12). Dimeric sesquiterpene thioalkaloids (2,3,5,6) were found to significantly inhibit anti-sheep erythrocyte plaque forming cell formation in mice spleen cells at 10^<-6> M concentration. At this concentration, 2,5 and 6 were found to exhibit no cytotoxicity to mice spleen cells, and 3 also showed only a little cytotoxicity. In addition, the inhibitory activity of several Nuphar alkaloids, dimeric sesquiterpene thioalkaloids (1,4,7,8), and monomeric sesquiterpene alkaloids (9,10,11,12) on anti-sheep erythorocyte plaque forming cell formation was examined and some structural requirement of Nuphar alkaloid for immunosuppressive activity was determined.
- 公益社団法人日本薬学会の論文
- 1996-09-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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YAMAHARA Johji
Research Institute for Production Development
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Yamahara J
Kyoto Pharmaceutical University
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Shimoda Hiroshi
Research & Development Division Oryza Oil & Fat Chemical Co. Ltd.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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