Synthesis and the Intestinal Glucosidase Inhibitory Activity of 2-Aminoresorcinol Derivatives toward an Investigation of Its Binding Site
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概要
- 論文の詳細を見る
2-Aminoresorcinol is a potent and selective intestinal glucosidase inhibitor. Unlike the majority of glucosidase inhibitors, it shows an uncompetitive mode of inhibition. In this study, we tested the intestinal glucosidase inhibitory activity of various 2-aminoresorcinol derivatives. We found that structural changes, in amino and two phenolic hydroxyl groups had a negative impact on inhibitory activity, but methylation of the phenolic hydroxyl group was found to maintain its activity and replacement of the aromatic ring with an acyl or alkoxy carbonyl group at the 4th position also retained its activity. This enable us to design a molecular probe for further study of the inhibition mechanism of 2-aminoresorcinol.
- 2012-05-23
著者
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Kawabata J
Hokkaido Univ. Sapporo Jpn
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Kawabata Jun
Graduate School Of Agriculture Hokkaido University
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Kawabata Jun
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Kawabata Jun
Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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Kato Eisuke
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Kawabata Jun
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Takahashi Keisuke
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Takahashi Keisuke
Laboratory Of Aquacultural Biology Graduate School Of Agricultural Science Tohoku University
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Oikawa Kenichi
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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TAKAHASHI Keisuke
Laboratory of Aguacultural Biology, Graduate School of Agricultural Science, Tohoku University
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