Acetyl-CoA Carboxylase Inhibitors from Avocado (Persea americana Mill) Fruits(Food & Nutrition Science)
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概要
- 論文の詳細を見る
A methanol extract of avocado fruits showed potent inhibitory activity against acetyl-CoA carboxylase, a key enzyme in fatty acid biosynthesis. The active principles were isolated and identified as (5E,12Z,15Z)-2-hydroxy-4-oxoheneicosa-5, 12, 15 - trienyl (1), (2R,12Z,15Z)-2-hydroxy-4-oxoheneicosa-12, 15-dienyl (2), (2R^*, 4R^*)-2, 4-dihydroxyheptadec-16-enyl (3) and (2R^*, 4R^*)-2, 4-dihydroxyheptadec-16-ynyl (4) acetates by instrumental analyses. The IC_<50> of the compounds were 4.0×10^<-6>, 4.9×10^<-6>, 9.4×10^<-6>, and 5.1×10^<-6>M, respectively.
- 社団法人日本農芸化学会の論文
- 2001-07-23
著者
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Ueda Chihoko
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Kawabata Jun
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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KASAI Takanori
Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hok
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Kasai Takanori
Laboratory Of Food Biochemistry Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkai
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HASHIMURA Hironori
Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hok
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Kawabata Jun
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Kasai Takanori
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Hashimura Hironori
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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