Administration of Anti-Asialo GM1 Serum Increases Aberrant Crypt Foci Induced by 1, 2-Dimethylhydrazine in the Large Bowel of Rats
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the influence of the administration of anti-asialo GM1 antibody on aberrant crypt foci (ACF) formation induced by a single injection of 1, 2-dimethylhydrazine (DMH). At four weeks after the injection of DMH (20mg/kg body weight), the number of ACF and aberrant crypts were counted. Most ACF appeared in the distal large bowel, accounting for approximately 60% of the total ACF in both groups. Rats administered anti-asialo GM1 had significantly more ACF in the distal colon, the rectum and the total large bowel as compared to control rats. A similar tendency was observed for the number of aberrant crypts. The increased number of ACF resulting from the administration of anti-asialo GM1 was not accompanied by the enlargement of ACF size in every part of the colon. This study demonstrated that the administration of anti-asialo GM1 at the initiation stage leads to an increase in ACF as well as aberrant crypts in the distal colon, rectum and total large bowel probably via the suppression of natural killer cells.
- 財団法人 学会誌刊行センターの論文
著者
-
Kasai Takanori
Laboratory Of Food Biochemistry Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkai
-
ISHIZUKA Satoshi
Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Research Faculty of Agricult
-
NAGAI Takumi
Laboratory of Nutritional Biochemistry, Department of Bioscience and Chemistry, Faculty of Agricultu
-
KASAI Takanori
Laboratory of Nutritional Biochemistry, Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
-
ISHIZUKA Satoshi
Laboratory of Nutritional Biochemistry, Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
-
NAGAI Takumi
Laboratory of Nutritional Biochemistry, Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
-
ISHIZUKA Satoshi
Laboratory of Food Biochemistry, Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
関連論文
- Inhibitory Effects of Ellagi- and Gallotannins on Rat Intestinal α-Glucosidase Complexes
- α-Glucosidase Inhibitors from Clove (Syzgium aromaticum)
- Structure-activity Relationships for α-Glucosidase Inhibition of Baicalein, 5,6,7-Trihydroxyflavone : the Effect of A-Ring Substitution
- 6-Hydroxyflavonoids as α-Glucosidase Inhibitors from Marjoram (Origanum majorana) Leaves(Food & Nutrition Science)
- Quinone Hemiacetal Formation from Protocatechuic Acid during the DPPH Radical Scavenging Reaction(Organic Chemistry)
- Acetyl-CoA Carboxylase Inhibitors from Avocado (Persea americana Mill) Fruits(Food & Nutrition Science)
- Apolipoprotein B mRNA Editing in the Liver and Small Intestine of Rats Fed on Beet Fiber, Soy Protein, and Fish Oil.
- Non-effect of hexamethonium, a ganglionic blocker, on the response of ileal apolipoprotein A-IV mRNA following a massive small bowel resection in rats
- Hibiscus Acid as an Inhibitor of Starch Digestion in the Caco-2 Cell Model System(Food & Nutrition Science)
- α-Amylase Inhibitors from Roselle (Hibiscus sabdariffa Linn.) Tea
- Improved Isolation Methods for Mucosal Leukocytes from Small and Large Intestines in Rats
- The Large Intestine Compensates for Insufficient Calcium Absorption in the Small Intestine in Rats
- Dietary Wheat Bran Modulates Proliferating Cell Nuclear Antigen-Labeling Index of the Rat Colorectum after Treatment with 1, 2-Dimethylhydrazine
- Administration of Anti-Asialo GM1 Serum Increases Aberrant Crypt Foci Induced by 1, 2-Dimethylhydrazine in the Large Bowel of Rats
- Supplementation of Methionine to a Low Soybean Protein Diet Strikingly Increases Pancreatic Amylase Activity in Rats
- Food Deprivation Increases Apoptotic Cell Counts Induced by 1,2-Dimethylhydrazine in Rat Descending Colonic and Rectal Crypts.