Food Deprivation Increases Apoptotic Cell Counts Induced by 1,2-Dimethylhydrazine in Rat Descending Colonic and Rectal Crypts.

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概要

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• The frequency of apoptosis after treatment with 1, 2-di-methylhydrazine (DMH) was counted in the descending colonic and rectal crypts of food-deprived and fed rats. Food-deprived or fed rats were subcutaneously injected with DMH (100 mg/kg body weight). Six hours after the injection, apoptosic cells were observed in crypt regions by light microscopy. The incidence of DMH-induced apoptosis in food-deprived rats was significantly higher than in fed rats. The incidence appeared to be higher in descending colon than in rectum. PAS staining revealed that DMH treatment lowered mucin secretion in crypts, which was substantially lowered by food deprivation. The effect of food depri-vation on apoptosis induced by DMH may be due to the decrease in mucus barrier against DMH.

• 財団法人 学会誌刊行センターの論文

著者

• Sonoyama Kei

  Laboratory Of Food Biochemistry Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkai

• Niki Ryoya

  Laboratory Of Food Biochemistry Faculty Of Agriculture Hokkaido University

• ISHIZUKA Satoshi

  Laboratory of Food Biochemistry, Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University

• NIKI Ryoya

  Laboratory of Food Biochemistry Department of Bioscience and Chemistry, Faculty of Agriculture Hokkaido University

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