Effects of Citrus unshiu Powder on the Cytokine Balance in Peripheral Blood Mononuclear Cells of Patients with Seasonal Allergic Rhinitis to Pollen
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概要
- 論文の詳細を見る
We evaluated the effects of a 50% methanol extract of Citrus unshiu powder (MEC) on cytokines in peripheral blood mononuclear cells (PBMCs) obtained from patients with seasonal allergic rhinitis to cedar pollen. The levels of cytokines, such as TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-12 (p70), IL-13, and GM-CSF, produced by pollen-stimulated PBMC were measured. We found that MEC suppressed pollen-induced TNF-α release and increased IFN-γ release from PBMCs. The results suggest that Citrus unshiu powder has an immunomodulatory effect in vitro and that its use could improve seasonal allergic rhinitis symptoms.
- 社団法人 日本農芸化学会の論文
- 2007-11-23
著者
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Sugiyama Masanori
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
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Sugiyama Masanori
Dep. Of Molecular Microbiology And Biotechnology Graduate School Of Biomedical Sciences Hiroshima Un
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Sugiyama M
Department Of Molecular Microbiology And Biotechnology Graduate School Of Biomedical Sciences Hirosh
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Sugiyama Masanori
Department Of Molecular Microbiology And Biotechnology Hiroshima University
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Tanabe Soichi
Graduate School Of Biosphere Sci. Hiroshima Univ.
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Kobayashi Shoko
Department Of Food And Life Science Takasaki University Of Health And Welfare
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Takido Naondo
Takido Medical Clinic
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KINUTA Yuki
Graduate School of Biosphere Science, Hiroshima University
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YASUMATSU Hatsumi
Graduate School of Biosphere Science, Hiroshima University
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TAKAYANAGI Masayoshi
Central Research Laboratory, Nitto Fuji Milling Co.
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Sugiyama Masanori
Department Of Molecular Microbiology And Biotechnology Graduate School Of Biomedical Sciences Hirosh
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Kinuta Yuki
Graduate School Of Biosphere Science Hiroshima University
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Takayanagi Masayoshi
Central Research Laboratory Nitto Fuji Milling Co.
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Yasumatsu Hatsumi
Graduate School Of Biosphere Science Hiroshima University
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Sugiyama Masanori
Department of Molecular Microbiology and Biotechnology, Graduate School of Biomedical Sciences, Hiroshima University:Frontier Center for Microbiology, Hiroshima University
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Kobayashi Shoko
Department of Allergy and Immunological Diseases, Tokyo Metropolitan Komagome Hospital
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