Role of Lipophilicity and Hydrogen Peroxide Formation in the Cytotoxicity of Flavonols
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概要
- 論文の詳細を見る
We compared the lipophilicity and toxicity of the four flavonols, galangin, kaempferol, quercetin and myricetin, which respectively have no, one, two and three hydroxyl groups on the B-ring. The lipophilicity was in the order of myricetin <quercetin<kaempferol<galangin. The cytotoxicity determined by a colony-formation assay with Chinese hamster lung fibroblast V79 cells was in the order of quercetin<kaempferol<galangin<myricetin. Apart from myricetin, the order of lipophilicity was the same as that of cytotoxicity, implying that the cytotoxicity was attributable to the lipophilicity. The cytotoxicity of myricetin was attributable to the hydrogen peroxide formed by autoxidation.
- 社団法人日本農芸化学会の論文
- 2001-05-23
著者
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Kumazawa S
Laboratory Of Functional Food Science And Global Coe Program In The 21st Century School Of Food And
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Kumazawa S
School Of Food And Nutritional Sciences University Of Shizuoka
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Kumazawa Shigenori
静岡県立大学 食品栄養科学部
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Nakayama Tsutomu
School of Food and Nutritional Sciences, University of Shizuoka
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Kumazawa Shigenori
School Of Food And Nutritional Sciences University Of Shizuoka
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Kumazawa Shigenori
Mcc-group Science & Technology Research Center Mitsubishi Chemical Corporation
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KAJIYA Katsuko
School of Food and Nutritional Sciences and COE program of 21st Century, University of Shizuoka
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ICHIBA Megumi
School of Food and Nutritional Sciences, University of Shizuoka
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KUWABARA Miho
School of Food and Nutritional Sciences, University of Shizuoka
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Kajiya Katsuko
Laboratory Of Functional Food Science And Global Coe Program In The 21st Century School Of Food And
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Kumazawa Shigenori
School Of Food And Nutritional Sciences And Coe Program Of 21st Century University Of Shizuoka
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Ichiba Megumi
School Of Food And Nutritional Sciences University Of Shizuoka
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Nakayama T
Laboratory Of Functional Food Science And Global Coe Program In The 21st Century School Of Food And
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Nakayama Tsutomu
School Of Food And Nutritional Sciences University Of Shizuoka
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Kuwabara Miho
School Of Food And Nutritional Sciences University Of Shizuoka
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