Superoxide Dismutase Inhibition of Oxidation of Ubiquinol and Concomitant Formation of Hydrogen Peroxide
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概要
- 論文の詳細を見る
We measured ubiquinone (CoQ_0) and hydrogen peroxide (H_2O_2) formed in the process of oxidation of ubiquinol (CoQ_0H_2). We found that copper-zinc superoxide dismutase and manganese superoxide dismutase inhibited both the CoQ_0 formation and the H_2O_2 formation only in the presence of chelators such as DTPA (diethylenetriaminepentaacetic acid). The amount of H_2O_2 was almost equal to that of CoQ_0, indicating that the H_2O_2 formation was coupled with the CoQ_0 formation. The lack of inhibitory effects of the corresponding heat-inactivated superoxide dismutase (SOD) confirmed that the inhibition by the original SOD was due to its enzymatic activity. We propose that CoQ_0H_2 oxidation occurs as a chain reaction with superoxide as the chain carrier and that SOD inhibits this reaction by lowering the superoxide concentration.
- 社団法人日本農芸化学会の論文
- 1997-12-23
著者
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Nakayama Tsutomu
School of Food and Nutritional Sciences, University of Shizuoka
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Hashimoto Kei
School Of Food And Nutritional Sciences The University Of Shizuoka
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Nakayama Tsutomu
School Of Food And Nutritional Sciences University Of Shizuoka
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HASHIMOTO Miku
School of Food and Nutritional Sciences, University of Shizuoka
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Hashimoto Miku
School Of Food And Nutritional Sciences University Of Shizuoka
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