Effects of Exercise on Plasma Concentrations of Caffeine and Its Metabolites in Horses
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概要
- 論文の詳細を見る
The effects of exercise on the metabolism of caffeine (CA) were studied 3 h after administration of the drug to race horses which then underwent exercise sets (1000-m gallop). Analysis was made of pharmacokinetics of CA, changes in its plasma concentrations, its metabolites, i.e., theophylline (TP), theobromine (TB) and paraxanthine (PX), and the molar concentration ratios of CA to these metabolites. After exercise, AUC and t_<1/2> tended to decrease, and the concentration of CA decreased, while the concentrations of TP and TB significantly increased. The TP/CA ratio and TB/CA ratio significantly increased from 6 to 74h and from 25 to 50h after drug administration, respectively. This indicated promotion of metabolism of CA into TP and TB. The effects on PX were minimal.
- 公益社団法人日本薬学会の論文
- 1995-11-15
著者
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鈴木 悦子
Laboratory Of Racing Chemistry
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百瀬 篤
(財)競走馬理化学研究所
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百瀬 篤
Laboratory Of Racing Chemistry 4-37-6 Kamiyoga Setagaya-ku Tokyo
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百瀬 篤
Laboratory Of Racing Chemistry
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石高 治
Laboratory Of Racing Chemistry
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荒牧 すが子
Laboratory of Racing Chemistry
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Suzuki E
Hoechst Marion Roussel Ltd. Kawagoe Jpn
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Suzuki Ei-ichiro
Institute Of Life Sciences Ajinomoto Co Inc
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鈴木 恵理香
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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