ガスクロマトグラフと直結した質量分析計(GC-MS)によるDoping検査の研究(第4報)ガスクロマトグラフィーおよびマススペクトロメトリーによる局所麻酔薬の分析

概要

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Gas chromatographic and mass spectrometric properties of 14 kinds of local anesthetics were studied in order to obtain a basic information on their detection and identification in urine. A satisfactory separation of these drugs was achieved by gas chromatography using 2% OV-17,3% XE-60,and 0.5% Thermol-3 columns. In the mass spectra of these drugs, the molecular ion appeared as the peaks with a very low intensity except in the case of benzocaine, cocaine, and tropacocaine. Most of the intesive peaks were present in the relatively low mass region. The fragmentation processes were very simple and many characteristic fragments based on the structure of these drugs were observed.
公益社団法人日本薬学会の論文
1973-07-25