Unsaturated Fatty Acids and Pain
スポンサーリンク
概要
- 論文の詳細を見る
Fatty acids, which are the essential nutrients for humans, are an important source of energy and an essential component of cell membranes. They also function as signal transduction molecules in a range of biological phenomena. Recently, an increasing number of physiologic and pharmacologic reports on fatty acids have improved our understanding of the association of fatty acids with certain diseases. It has also become apparent that functional properties of fatty acids are modulated by factors such as the amount of individual fatty acid intake and their distribution among organs. Recently, the functional relationship between polyunsaturated fatty acids and pain has been the focus of many studies. Both basic and clinical studies have shown that a dietary intake of n-3 series polyunsaturated fatty acids results in a reduction in the pain associated with rheumatoid arthritis, dysmenorrhea, inflammatory bowl disease, and neuropathy. In addition, levels of n-6 series polyunsaturated fatty acids are high in patients with chronic pain. These results indicate that polyunsaturated fatty acids play a vital role in pain regulation. In this review, we summarize a number of basic and clinical studies on polyunsaturated fatty acids and their association with pain.
著者
-
Nakamoto Kazuo
Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences
-
Tokuyama Shogo
Department Of Clinical Pharmacy Kobe Gakuin University Faculty Of Pharmaceutical Sciences
-
NAKAMOTO Kazuo
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
-
Nakamoto Kazuo
Department of Chemistry, Faculty of Science, Osaka University
関連論文
- Antinociceptive Effects of Docosahexaenoic Acid against Various Pain Stimuli in Mice
- Preventive Effect of Morinda citrifolia Fruit Juice on Neuronal Damage Induced by Focal Ischemia(Pharmacognosy)
- Effects of Docosahexaenoic Acid in an Experimental Rat Model of Nonalcoholic Steatohepatitis
- The Antinociceptive and Anti-inflammatory Action of the CHCl3-Soluble Phase and Its Main Active Component, Damnacanthal, Isolated from the Root of Morinda citrifolia
- Effect of Orexin-A on Post-ischemic Glucose Intolerance and Neuronal Damage
- Involvement of Adenosine A_2 Receptors in the Changes of Tissue Factor-Dependent Coagulant Activity Induced by Polymorphonuclear Leukocytes in Endothelial Cells
- Induction and Inhibition of Cytochrome P450 and Drug-Metabolizing Enzymes by Climbazole
- CLIMBAZOLE IS A NEW POTENT INDUCER OF RAT HEPATIC CYTOCHROME P450
- Changes of Tissue Factor-Dependent Coagulant Activity Mediated by Adhesion Between Polymorphonuclear Leukocytes and Endothelial Cells
- Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-Metabolizing Enzymes in Vivo and in Vitro
- SEX-RELATED EFFECT OF HEMIN ON CYTOCHROME P450 AND DRUG-METABOLIZING ENZYMES IN RAT LIVER
- Antigenic characterization in ampiroxicam-induced photosensitivity using an in vivo model of contact hypersensitivity
- Regulatory Action of Nitric Oxide Synthase on Ileal P-glycoprotein Expression under Streptozotocin-Induced Diabetic Condition
- A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice
- Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration : a Comparative Study with Morphine
- Morinda citrifolia fruit juice prevents ischemic neuronal damage through suppression of the development of post-ischemic glucose intolerance
- Participation of GABAergic Systems in the Production of Antinociception by Various Stresses in Mice
- Unsaturated Fatty Acids and Pain
- Negative Relationship Between Morphine Analgesia and P-Glycoprotein Expression Levels in the Brain
- Further Evidence for the Participation of an α_2-Adrenoceptor Mediated Mechanism in the Production of Forced Swimming-Stress Induced Analgesia in Mice
- PARTICIPATION OF AN α2-MEDIATED MECHANISM IN THE PRODUCTION OF FORCED SWIMMINGSTRESS INDUCED ANALGESIA IN MICE
- The Opioid Activity and Receptor Selectivity of Fluorinated Leu^5 Enkephalin Analogues in Vitro and in Vivo
- Neurosteroids stimulate G protein-coupled sigma receptors in mouse brain synaptic membrane
- Effect of Orexin-A on Post-ischemic Glucose Intolerance and Neuronal Damage
- Ameliorating Effect of Hypothalamic Brain-Derived Neurotrophic Factor Against Impaired Glucose Metabolism After Cerebral Ischemic Stress in Mice
- Ischemic Stroke and Glucose Intolerance : a Review of the Evidence and Exploration of Novel Therapeutic Targets
- The Involvement of Cleavage of Neural Cell Adhesion Molecule in Neuronal Death under Oxidative Stress Conditions in Cultured Cortical Neurons
- Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice
- Dichroisms of Benzene Rings. III. The Dichroism of m-Nitronitrosobenzene Monomer
- Functional Alterations of Intestinal P-Glycoprotein under Diabetic Conditions
- Distinctive implication of emotional factors in various types of stress-induced analgesia.
- Radixin Influences the Changes in the Small Intestinal P-Glycoprotein by Etoposide Treatment
- Blockade by Ginseng Extract of the Development of Reverse Tolerance to the Ambulation-Accelerating Effect of Methamphetamine in Mice.
- Further evidence for the implication of a .KAPPA.-opioid receptor mechanism in the production of psychological stress-induced analgesia.
- Anti-Stress Effect of Ginseng on the Inhibition of the Development of Morphine Tolerance in Stressed Mice.
- Blockade of the development of analgesic tolerance to morphine by psychological stress through benzodiazepine receptor mediated mechanism.
- Involvement of Serotonergic Receptor Subtypes in the Production of Antinociception by Psychological Stress in Mice.