DEVELOPMENT OF PHYSICAL DEPENDENCE ON MORPHINE NOT ACCOMPANIED WITH TOLERANCE FORMATION
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概要
- 論文の詳細を見る
The development of tolerance induced by daily repeated administration of 10 mg/kg of s. c. morphine was suppressed by combined injection of adrenergic blockers, 10 mg/kg i. p. phentolamine or propranolol, in mice. However, this treatment could not prevent the development of physical dependence as evidenced by the naloxone precipitated abstinence signs. Thus, we provide a new evidence that morphine analgesia, tolerance and physical dependence is dissociable from each other.
- 公益社団法人日本薬学会の論文
著者
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KANETO Hiroshi
Emeritus Professor, Nagasaki University
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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OHTA Aya
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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Ohta Aya
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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