Diversity of underlying mechanisms in the production of analgesic and pentobarbital-hypnosis prolonging effects of various analgesic drugs and stresses.
スポンサーリンク
概要
- 論文の詳細を見る
Stressful stimuli, electric footshock (FS), immobilized-water immersion (IW), and cold-water swimming (CWS), produced analgesia and prolonged the pentobarbital hypnosis as well as morphine and clonidine. Naloxone completely antagonized the analgesic effects of morphine and FS and partially that of IW; however, that of clonidine and CWS were not reversed by naloxone. Naloxone eliminated the hypnosis prolonging effect of morphine and FS, but failed to reverse the effect of clonidine, IW and CWS. Differences in the analgesic and hypnosis prolonging effects and also the respective naloxone sensitivity of each drug and stress suggest the diversity of the underlying mechanisms.
- 公益社団法人 日本薬理学会の論文
著者
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Kaneto Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Nagasaki University
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HANADA Seigo
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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DEGUCHI Yoshiki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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