Effects of Tyr-MIF-1 on Stress-Induced Analgesia and the Blockade of Development of Morphine Tolerance by Stress in Mice

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概要

• 論文の詳細を見る

• The role of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) in biological responses to stress exposure was examined in mice. Intraperitoneal or intracerebroventricular administration of Tyr-MIF-1 attenuated not only footshock (FS)- and forced swimming (SW)-stress-induced analgesia (SIA) but also socio-psychological (PSY)-SIA that, when using the communication box, is produced without any direct physical nociceptions. Tyr-MIF-1 also disrupted the suppressive effect of concurrent exposure to FS- and PSY-stress on the development of morphine antinociceptive tolerance. In elevated-plus-maze tests, mice treated with Tyr-MIF-1 tended to spend more time in the open arms compared with the control group, suggesting the anxiolytic properties of the peptide. Thus, the finding that Tyr-MIF-1 modulates these stress responses suggests that the peptide regulates an endogenous biological alert system responding to stress exposure, perhaps, counteracting the excessive response of the system. Furthermore, Tyr-MIF-1, in the case of PSY-stress, through the attenuation of emotional factors such as fear and anxiety, may suppress PSY-SIA and inhibition by PSY-stress of the development of morphine tolerance.

• 社団法人 日本薬理学会の論文
• 1999-02-01

著者

• YOSHIKAWA Masaaki

  Research Institute for Food Science, Kyoto University

• TAKAHASHI Masakatsu

  Department of Respiratory Medicine, Kanazawa Medical University

• Yoshikawa Masaaki

  Research Institute For Food Science Kyoto University

• Yoshikawa Masaaki

  Department Of Clinical Pharmacology School Of Medicine Tokai University

• FUKUNAGA Hiroko

  Department of Pharmacoinformatics, School of Pharmaceutical Sciences, Nagasaki University

• KANETO Hiroshi

  Emeritus Professor, Nagasaki University

• Fukunaga Hiroko

  Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University

• Takahashi M

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University

• Takahashi Masakatsu

  Department Of Pharmacoinformatics School Of Pharmaceutical Sciences Nagasaki University

• Kaneto Hiroshi

  Emeritus Professor Nagasaki University

• Kaneko Hiroshi

  Emeritus Professor, Nagasaki University

• Takahashi Masakatsu

  Department of Analytical Research for Pharmacoinformatics, Graduate School of Pharmaceutical Sciences, Nagasaki University

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