Dose-response Effects of Exercise Intensity on Bone in Ovariectomized Rats

スポンサーリンク

概要

• 論文の詳細を見る

• The purpose of this study was to investigate the effects of different intensities of resistance exercise training on established bone loss in ovariectomized (ovx-ed) rats by densitometry and histomorphometry. Thirty Female Wistar rats were ovx-ed or sham-operated (SHM) at 3 months of age and maintained untreated for 5 months after surgery to establish osteopenia. When they reached 8 months, the ovx-ed rats were divided into four groups in accordance with varying weights applied to a squat-training device: The weight classifications were 1) kept sedentary (OVX); 2) lifted 0 g (LOW); 3) 750 g (MID); and 1500 g (HIGH). The rats in the three training groups performed weight-lifting of 10 reps, performing 2 sets per day, 3 days a week for a ten week period. The Femora and tibiae were removed from each rat and were used for analyses. Ovx induced a significant loss of total BMC in all the bones tested. The ovx-induced femoral BMC loss was observed at all locations tested on the bone (proximal, shaft, and distal), and exercise-intensity dependent restoration was found at the proximal and the distal sites, but not at the shaft. In the tibia, ovx-induced significant bone loss occurred only at the proximal metaphyseal site. The training increased the tibial BMC of all sites in an exercise-intensity dependently, irrespective of the degree of ovx effect. At the tibial shaft, the training increased the cortical bone mass significantly above sham level by the bone apposition at the periosteum. At the proximal tibial metaphysis, exercise had no effect on the cancellous bone volume after ovx-induced bone loss. This finding suggests that the exercise induced bone increase in the ovx-ed rats was from cortical bone, not from cancellous bone, at least in the proximal tibia. These findings indicate that the weight-lifting exercise in rats reversed the ovx-induced bone loss in an exercise-intensity dependent and site-specific manner, even in established osteopenic skeleton 5 mon after ovx.

• Japan Society of Physical Education, Health and Sport Sciencesの論文

著者

• FUKUYAMA Ryo

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University

• Izumo Nobuo

  Department Of Pharmacology Daiichi College Of Pharmaceutical Sciences

• Nakamuta Hiromichi

  Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Hiroshima International University

• Tanaka Ippei

  Research Scientist Pharmacology Group 2, Research Laboratories 2, Fuji Yakuhin Co. Ltd.

• Shimegi Satoshi

  Laboratory of Cognitive and Behavioral Neuroscience, Graduate School of Medicine, Osaka University

• Kiuchi Atsushi

  Section for Health-Related Physical Education, Faculty of Intellectual Property, Osaka Institute of Technology

関連論文

• The Functional Involvement of Rac on Bone and Tooth Formation : Characteristic of N17Rac Transgenic Mice(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
• Transactivation of Core Binding Factor α1 as a Basic Mechanism to Trigger Parathyroid Hormone-Induced Osteogenesis
• Incadronate and Etidronate Accelerate Phosphate-Primed Mineralization of MC4 Cells via ERK1/2-Cbfa1 Signaling Pathway in a Ras-Independent Manner: Further Involvement of Mevalonate-Pathway Blockade for Incadronate
• Phosphate Stimulates Differentiation and Mineralization of the Chondroprogenitor Clone ATDC5
• Bone-anabolic Effect of Salmon Calcitonin on Glucocorticoid-Induced Osteopenia in Rats
• Bone Anabolic Effects of PTH(1-34) and Salmon Calcitonin in Ovariectomy- and Ovariectomy-Steroid-Induced Osteopenic Rats: A Histomorphometric and Biomechanical Study
• Anti-Osteoporotics for New Century : Now and Then(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
• Antihypertensive Effects of Continuous Oral Administration of Nattokinase and Its Fragments in Spontaneously Hypertensive Rats
• Anti-osteoporosis Effect of 5-Bromo-2-(4-chlorobenzoyl)-(Z)-3-(2-cyano-3-hydroxybut-2-enonyl)aminobenzo[b]furan : a Novel Selective Estrogen Receptor Modulator
• Dose-response Effects of Exercise Intensity on Bone in Ovariectomized Rats

スポンサーリンク