Hypocholesterolemic Effects of Microbial Protease-Resistant Fraction of Katsuobushi in Ovariectomized Rats Depend on the Both Oil and Undigested Protein
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to examine which component in the microbial protease-resistant fraction of Katsuobushi (KBR), smoke-dried bonito, is hypocholesterolemic in ovariectomized rats (OVX-rats). KBR contains two major components: oil and protease-resistant protein. Oil extracted from KBR (EX) was rich in palmitic, oleic and docosahexaenoic acids. OVX-rats were fed one of the following diets for 28d: diets containing casein as the protein source (C or C+EX diet), a diet containing KBR as the protein source (KBR diet) or diets containing degreased KBR as the protein source (DF/KBR or DF/KBR+EX diet). The C and DF/KBR diets contained soybean oil as the oil source. In the C+EX, KBR and DF/KBR+EX diets, soybean oil was replaced by oil extracted from KBR (EX). Plasma total- and low density lipoprotein-cholesterol concentrations in the C+EX, KBR and DF/KBR+EX groups, but not in the DF/KBR group, were significantly lower than that in the C group. Fecal bile acid excretion was significantly greater in the C+EX, KBR, DF/KBR and DF/KBR+EX groups in comparison to the C group, whereas excretion in the KBR and DF/KBR+EX groups was significantly greater than in the C+EX and DF/KBR groups. Cholesterol 7α-hydroxylase activity was higher in the C+EX, KBR, DF/KBR and DF/KBR+EX groups than the C group. In OVX-rats fed C, C+EX or KBR for 28d, bile acid flux into the small intestine increased in KBR and C+EX groups in comparison to the C group. The hypocholesterolemic effect of KBR in OVX-rats reflected in increased fecal bile acid excretion may be mediated by increased bile acid flux caused by EX and the binding of bile acids by protease-resistant proteins.
- 日本ビタミン学会の論文
著者
-
KISHIDA Taro
Department of Applied Bioscience, Faculty of Agriculture, Ehime University
-
EBIHARA Kiyoshi
Department of Applied Bioscience, Faculty of Agriculture, Ehime University
-
DOI Mikiharu
Marutomo Co., Ltd.
-
Ogawa Hiroshi
Faculty of Science and Engineering, Saga university
-
Doi Mikiharu
Marutomo Co. Ltd.
-
Doi Mikiharu
Marutomo Co. Ltd
-
Kishida Taro
Department Of Applied Bioscience Faculty Of Agriculture Ehime University
-
Matsumoto Junichi
Marutomo Co. Ltd.
-
ERAMI Kazuo
Department of Biological Resources, Faculty of Agriculture, Ehime University
-
ENAMI Kazuo
Department of Biological Resources, Faculty of Agriculture, Ehime University
-
Kishida Taro
Fac. Of Agriculture Ehime Univ.
-
Ebihara Kiyoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Ehime University
-
Ogawa Hiroshi
Faculty Of Human And Cultural Studies Tezukayamagakuin University
-
KISHIDA Taro
Department of Applied Bioresource Science, The United Graduate School of Agricultural Sciences, Ehime University
関連論文
- Difructose Anhydride III Does Not Contribute to Body Energy Accumulation in Rats
- Immunostimulation Effect of Jellyfish Collagen
- Growth of Tungsten Films on Tool Steel Substrates by rf Magnetron Sputtering
- Mode of Action of the Immunostimulatory Effect of Collagen from Jellyfish
- Optical Analysis of Reduction Products of 2-Methylcyclohexanone by Aspergill s repens MA0197
- Adymmetric Reduction of Acetophenone by Aspergillus Species and Their Possible Contribution to Katsuobushi Flavor
- Microbial Degradation of BHA in Niboshi(Boiled and Dried Anchovy) by Aspergillus Species(Food & Nutrition)
- O-Methylation of o-Alkoxyphenols by Aspergillus repens MA0197(Microbiology & Fermentation Industry)
- Biological Isomerization of Cyclohexanols by Aspergillus repens MA0197(Microbiology & Fermentation Industry)
- O-Methylation of Phenols by Aspergillus repens MA0197(Microbiology & Fermentation Industry)