Mode of Action of the Immunostimulatory Effect of Collagen from Jellyfish

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概要

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• We have previously demonstrated that collagen from jellyfish simulated immunoglobulin and cytokine production by human-human hybridoma line HB4C5 cells and by human peripheral blood lymphocytes (hPBL). The mode of action of the collagen as an immunostimulatory factor was investigated. The expression levels of immunoglobulin mRNAs in HB4C5 cells, and those of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and transforming growth factor (TGF)-β in hPBL were up-regulated by jellyfish collagen. In addition, this collagen activated IgM production by transcription-suppressed HB4C5 cells that had been treated with actinomycin D. This collagen also enhanced IgM production by translation-suppressed HB4C5 cells that had been treated with sodium fluoride, but was ineffective in accelerating IgM production by HB4C5 cells treated with cycloheximide. Moreover, the intracellular IgM level in HB4C5 cells treated with the post-translation inhibitor, monensin, was increased by this collagen. These results suggest that collagen from jellyfish stimulated not only the transcription activity, but also the translation activity for enhanced immunoglobulin and cytokine production.

• 社団法人 日本農芸化学会の論文
• 2008-11-23

著者

• NISHIMOTO Sogo

  Faculty of Agriculture, Ehime University

• SUGAHARA Takuya

  Faculty of Agriculture, Ehime University

• NISHIMOTO Sogo

  Center for Marine Environmental Studies, Ehime University

• Nishimoto Sogo

  Faculty Of Agriculture Ehime University

• Akiyama Koichi

  Faculty Of Agriculture Ehime University

• Akiyama Koichi

  Integrated Center For Sciences Tarumi Station Ehime Univ.

• Sugimoto Naoko

  Faculty Of Agriculture Ehime University

• Sugahara Takuya

  Faculty Of Agriculture Ehime University

• YAMAUCHI Satoshi

  Faculty of Agriculture, Ehime University

• GOTO Yoko

  Faculty of Agriculture, Ehime University

• SHIRAISHI Ryusuke

  Marutomo Co., Ltd.

• DOI Mikiharu

  Marutomo Co., Ltd.

• Morishige Hitoshi

  Faculty of Agriculture, Ehime University

• Doi Mikiharu

  Marutomo Co. Ltd

• Nishimoto Sogo

  Center For Marine Environmental Studies Ehime Univ.

• Sugahara Takuya

  Fac. Of Agriculture Ehime Univ.

• Yamauchi Satoshi

  Faculty Of Agriculture Ehime University

• Akiyama Koichi

  Integrated Center For Sciences (incs) Ehime University

• Shiraishi Ryusuke

  Marutomo Co. Ltd.

• Goto Yoko

  Faculty Of Agriculture Ehime University

• Yamauchi Satoshi

  Fac. Of Agriculture Ehime Univ.

• Morishige Hitoshi

  Faculty Of Agriculture Ehime University

• NISHIMOTO Sogo

  Center for Marine Environmental Studies (CMES), Ehime University

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