Improved Syntheses of Morinol C and D by Employing Mizoroki-Heck Reaction and Their Cytotoxic and Antimicrobial Activities
スポンサーリンク
概要
- 論文の詳細を見る
Improved syntheses of optically pure (−)- and (+)-morinol C, and (−)- and (+)-morinol D were achieved by employing the Mizoroki-Heck reaction to construct the cinnamyl moiety. The protective group of the alkene substrate affected the yield of this key reaction. The reaction with a combination of the acetate-protected olefin and 4-methoxyphenylboronic acid gave the best result producing morinol C and D. All stereoisomers of morinol C and D showed cytotoxic activity, with (R,R)-morinol C showing the highest antibacterial activity.
- 社団法人 日本農芸化学会の論文
- 2010-08-23
著者
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SUGAHARA Takuya
Faculty of Agriculture, Ehime University
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Akiyama Koichi
Faculty Of Agriculture Ehime University
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Akiyama Koichi
Integrated Center For Sciences Tarumi Station Ehime Univ.
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Sugahara Takuya
Faculty Of Agriculture Ehime University
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YAMAUCHI Satoshi
Faculty of Agriculture, Ehime University
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MARUYAMA Masafumi
Faculty of Agriculture, Ehime University
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Sugahara Takuya
Fac. Of Agriculture Ehime Univ.
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Yamauchi Satoshi
Faculty Of Agriculture Ehime University
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Akiyama Koichi
Integrated Center For Sciences (incs) Ehime University
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Maruyama Masafumi
Faculty Of Agriculture Ehime University
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OGURA Koji
Faculty of Agriculture, Ehime University
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Yamauchi Satoshi
Fac. Of Agriculture Ehime Univ.
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Maruyama Masafumi
Fac. Of Agriculture Ehime Univ.
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Ogura Koji
Faculty Of Agriculture Ehime University
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