Immunostimulatory in Vitro and in Vivo Effects of a Water-Soluble Extract from Kale
スポンサーリンク
概要
- 論文の詳細を見る
The water-soluble fraction of kale (Brassica oleracea L. var. acephala DC.) had immunoglobulin (Ig) production stimulating activity in human hybridoma HB4C5 cells and human peripheral blood lymphocytes. The biochemical and physical properties of the main active substance in kale were found to be a heat-stable protein with a molecular weight higher than 50 kDa. The Ig production-stimulating factors were assumed to act on the translational and/or secreting processes of Igs. This Ig production-stimulating effect was also observed in lymphocytes from the mesenteric lymph node and Peyer’s patches of mice that had been administered with the kale extract for 14 d. The partially purified kale extract was analyzed by LC-ESI-MS/MS, the result indicating ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) as an active substance. Rubisco from spinach indeed exhibited Ig production-stimulating activity in HB4C5 cells. These findings provide another beneficial aspect of kale as a health-promoting foodstuff.
著者
-
SUGAHARA Takuya
Faculty of Agriculture, Ehime University
-
NISHIMOTO Sogo
Center for Marine Environmental Studies, Ehime University
-
Nishi Kosuke
Faculty of Agriculture, Ehime University
-
Kondo Ai
Faculty of Agriculture, Ehime University
-
Okamoto Takeaki
Kawasaki Medical University
-
NAKANO Hiroyuki
Kawasaki Medical University
-
DAIFUKU Miho
Faculty of Agriculture, Ehime University
-
OCHI Kenji
Enseki Aojiru Inc.
-
TAKAOKA Terumi
Enseki Aojiru Inc.
-
Takaoka Terumi
Enseki Aojiru Co. Ltd.
-
Sugahara Takuya
Faculty Of Agriculture Ehime University
-
Okamoto Takeaki
Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
-
Nishimoto Sogo
Center For Marine Environmental Studies Ehime Univ.
-
Okamoto Takeaki
Kawasaki Medical Univ.
-
Kondo Ai
Faculty Of Agriculture Ehime University
-
Nishi Kosuke
Faculty Of Agriculture Ehime University
関連論文
- Proteose Peptone Fraction of Bovine Milk Depressed IgE Production in Vitro and in Vivo
- Oral administration of paraquat perturbs immunoglobulin productivity in mouse
- Effects of Vegetable Containing Gamma-Aminobutyric Acid on the Cardiac Autonomic Nervous System in Healthy Young People
- Immunostimulatory in vitro and in vivo effects of a water-soluble extract from kale
- Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe
- Immunostimulatory in Vitro and in Vivo Effects of a Water-Soluble Extract from Kale
- White Sorghum (Sorghum bicolor (L.) Moench) Bran Extracts Suppressed IgE Production by U266 Cells
- Antifungal Activity of Morinol B Derivatives of Tetrahydropyran Sesquilignan
- Heavy oil fractions induce negative influences on mouse immune system
- Tributyltin induces Yca1p-dependent cell death of yeast Saccharomyces cerevisiae
- Severe abnormalities in the reproductive organs of mice caused by chemical substances contained in heavy oil
- Antimicrobial Activity of Stereoisomers of Morinols A and B, Tetrahydropyran Sesquineolignans
- Stereoselective Construction of Tetra-Substituted Tetrahydrofuran Compounds from Benzylic Hemiacetal in the Presence of H2 and a Pd Catalyst: Stereoselective Synthesis of a Stereoisomer of (−)-Virgatusin and Its Antimicrobiological Activity
- Immunostimulation Effect of Jellyfish Collagen
- Antibacterial Activity of a Virgatusin-Related Compound
- Antifungal Activity of Tetra-Substituted Tetrahydrofuran Lignan, (−)-Virgatusin, and Its Structure-Activity Relationship
- Antimicrobiological Activity of Lignan: Effect of Benzylic Oxygen and Stereochemistry of 2,3-Dibenzyl-4-butanolide and 3,4-Dibenzyltetrahydrofuran Lignans on Activity
- Effect of Benzylic Oxygen on the Cytotoxic Activity for Colon 26 Cell Line of Phenolic Lignans
- Radical and Superoxide Scavenging Activities of Matairesinol and Oxidized Matairesinol
- Absolute Configuration of Volicitin from the Regurgitant of Lepidopteran Caterpillars and Biological Activity of Volicitin-Related Compounds
- The Effect of Secoisolariciresinol on 3T3-L1 Adipocytes and the Relationship between Molecular Structure and Activity
- Mode of Action of the Immunostimulatory Effect of Collagen from Jellyfish
- PD3-7 Acute Phase Effect on Cardiovascular and Autonomic Nervous Systems by Vegetable Juice Intake(Proceedings of The 8th International Congress of Physiological Anthropology)
- 1-10 Changes of EEG and Heart Rate Variability after Vegetable Juice Intake
- Enhanced Sequence Coverage in Tryptic Fragment Analysis by Two-Dimensional HPLC/MS Using a Monolithic Silica Capillary Column
- First Stereoselective Synthesis of meso-Secoisolariciresinol and Comparison of Its Biological Activity with (+) and (−)-Secoisolariciresinol
- Immunomodulatory Effect of (−)-Matairesinol in Vivo and ex Vivo
- Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe
- Inhibition of the Discoloration of Yellowtail Dark Muscle by Lignan
- IgE-Suppressive Activity of (-)-Matairesinol and Its Structure-Activity Relationship
- Antifungal Activity of Morinol B Derivatives of Tetrahydropyran Sesquilignan
- Antimicrobial Activity of Stereoisomers of Butane-Type Lignans
- Inhibition of the Discoloration of Yellowtail Dark Muscle by Lignan
- Syntheses and Antimicrobial Activity of Tetrasubstituted Tetrahydrofuran Lignan Stereoisomers
- Antimicrobial Activity of Stereoisomers of Morinols A and B, Tetrahydropyran Sesquineolignans
- The Effect of Secoisolariciresinol on 3T3-L1 Adipocytes and the Relationship between Molecular Structure and Activity
- Antioxidant Activity of Butane Type Lignans, Secoisolariciresinol, Dihydroguaiaretic Acid, and 7,7'-Oxodihydroguaiaretic Acid
- Syntheses of All Stereoisomers of Goniodiol from Yeast-Reduction Products and Their Antimicrobiological Activity
- Structure-Antibacterial Activity Relationship for 9-O,9'-O-Demethyl (+)-virgatusin
- Stereoselective Construction of Tetra-Substituted Tetrahydrofuran Compounds from Benzylic Hemiacetal in the Presence of H_2 and a Pd Catalyst : Stereoselective Synthesis of a Stereoisomer of (-)-Virgatusin and Its Antimicrobiological Activity
- First Stereoselective Synthesis of meso-Secoisolariciresinol and Comparison of Its Biological Activity with (+) and (-)-Secoisolariciresinol
- Antimicrobiological Activity of Lignan : Effect of Benzylic Oxygen and Stereochemistry of 2,3-Dibenzyl-4-butanolide and 3,4-Dibenzyltetrahydrofuran Lignans on Activity
- Antifungal Activity of Tetra-Substituted Tetrahydrofuran Lignan, (-)-Virgatusin, and Its Structure-Activity Relationship
- Antibacterial Activity of a Virgatusin-Related Compound
- Improved Syntheses of Morinol C and D by Employing Mizoroki-Heck Reaction and Their Cytotoxic and Antimicrobial Activities
- Proteose Peptone Fraction of Bovine Milk Depressed IgE Production in Vitro and in Vivo
- Mode of Action of the Immunostimulatory Effect of Collagen from Jellyfish
- Use of the Benzyl Mesylate for the Synthesis of Tetrahydrofuran Lignan: Syntheses of 7,8-trans, 7′,8′-trans, 7,7′-cis, and 8,8′-cis-Virgatusin Stereoisomers
- Gene Transfection into HeLa Cells by Vesicles Containing Cationic Peptide Lipid
- Heavy oil fraction induces the dysplastic sperm in male mouse
- Inhibition of myotube formation by paraquat in the myoblast cell line C2C12
- Immunostimulatory in Vitro and in Vivo Effects of a Water-Soluble Extract from Kale
- White Sorghum (Sorghum bicolor (L.) Moench) Bran Extracts Suppressed IgE Production by U266 Cells
- Increase of Immunoglobulin Productivity of Human-Human Hybridoma HB4C5 Cells by Histone(Biochemistry & Molecular Biology)
- Immunomodulatory Effect of (-)-Matairesinol in Vivo and ex Vivo
- Immunostimulation Effects of Yellowtail Heart Extracts in Vitro and in Vivo
- Effect of the Benzylic Structure of Lignan on Antioxidant Activity
- Disruption of Ion Homeostasis by Verrucosin and a Related Compound
- Heavy oil fraction induces the dysplastic sperm in male mouse
- High IgM Production by Human-human Hybridoma HB4C5 Cells Cultured in Microtubes(Microbiology & Fermentation Technology)