Antibacterial Activity of a Virgatusin-Related Compound
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概要
- 論文の詳細を見る
The relationship between antibacterial activity of tetra-substituted tetrahydrofuran lignans (1–4) and their absolute configurations was tested. Only compound 4 among two virgatusins and two related compounds exhibited growth inhibitory activity against the Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus and Listeria denitrificans. Compound 4 affected the growth of B. subtilis in a bactericidic manner, and its ability to dissipate the cytoplasmic membrane potential was investigated using the fluorescence probe 3,3′-dipropylthiadicarbocyanine iodide. These results suggested that compound 4 damages cells by causing the loss of the proton motive force and disruption of the cellular integrity of the membrane, leading to cell death. In addition, it was shown that the antibacterial activity of a lignan was closely related to its absolute configuration and functional groups.
- 社団法人 日本農芸化学会の論文
著者
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SUGAHARA Takuya
Faculty of Agriculture, Ehime University
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Akiyama Koichi
Faculty Of Agriculture Ehime University
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Akiyama Koichi
Integrated Center For Sciences Tarumi Station Ehime Univ.
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YAMAUCHI Satoshi
Faculty of Agriculture, Ehime University
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MARUYAMA Masafumi
Faculty of Agriculture, Ehime University
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KISHIDA Taro
Faculty of Agriculture, Ehime University
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KOBA Yojiro
Faculty of Agriculture, Ehime University
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