Immunostimulation Effects of Yellowtail Heart Extracts in Vitro and in Vivo
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概要
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The immunostimulation effects of yellowtail heart extracts were examined. Screening various parts of the yellowtail viscera, we found that extracts from the yellowtail heart enhanced IgM production by human hybridoma HB4C5 cells. Yellowtail heart extracts heated at 121 °C for 20 min and dialyzed showed the highest IgM production-stimulating activity toward HB4C5 cells. Also, immunoglobulin production by mouse spleen lymphocytes was stimulated by yellowtail heart extracts in vitro, and lymphocytes derived from mice administered the extract for 20 d were activated in vivo. Yellowtail heart extracts were partially purified by anion-exchange chromatography, and fractions containing a 33 kDa-protein exhibited immunostimulating activity. LC-MS/MS analysis revealed that the 33 kDa-protein was most similar to tropomyosin-4 from various fishes. Purified tropomyosin from porcine muscle enhanced IgM production by HB4C5 cells. This means that tropomyosin-4 is one of the immunostimulating substances in the yellowtail heart.
- 2011-04-23
著者
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NISHIMOTO Sogo
Faculty of Agriculture, Ehime University
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SUGAHARA Takuya
Faculty of Agriculture, Ehime University
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Nishimoto Sogo
Faculty Of Agriculture Ehime University
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Sugimoto Naoko
Faculty Of Agriculture Ehime University
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Nishi Kosuke
Faculty of Agriculture, Ehime University
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Okamoto Takeaki
Kawasaki Medical University
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NAKANO Hiroyuki
Kawasaki Medical University
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DAIFUKU Miho
Faculty of Agriculture, Ehime University
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Sugahara Takuya
Faculty Of Agriculture Ehime University
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Okamoto Takeaki
Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Nishimoto Sogo
Center For Marine Environmental Studies Ehime Univ.
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Sugahara Takuya
Fac. Of Agriculture Ehime Univ.
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Okamoto Takeaki
Kawasaki Medical Univ.
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Nishi Kosuke
Faculty Of Agriculture Ehime University
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Yamashita Hirofumi
Fisheries Research Center Ehime Research Institute Of Agriculture Forestry And Fisheries
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Nishikawa Satoshi
Fisheries Research Center Ehime Research Institute Of Agriculture Forestry And Fisheries
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YAGUCHI Yusuke
Faculty of Agriculture, Ehime University
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TAKIMOTO Shinichi
Fisheries Research Center, Ehime Research Institute of Agriculture, Forestry and Fisheries
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Daifuku Miho
Faculty Of Agriculture Ehime University
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Yaguchi Yusuke
Faculty Of Agriculture Ehime University
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Takimoto Shinichi
Fisheries Research Center Ehime Research Institute Of Agriculture Forestry And Fisheries
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NISHIMOTO Sogo
Center for Marine Environmental Studies (CMES), Ehime University
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