Increase of Immunoglobulin Productivity of Human-Human Hybridoma HB4C5 Cells by Histone(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
A histone mixture (H1, H2A, H2B, H3, and H4) derived from calf thymus stimulated IgM production by human-human hybridoma HB4C5 cells. On the contrary, the histone mixture did not increase IgM production by the human Burkitt's lymphoma cell line NAT-30, IgG production by the human B lymphoblastoid cell line HMy-2, and IgE production by the human myeloma cell line U266. The immunoglobulin production-stimulating activity of the histone mixture was inactivated by trypsin or chymotrypsin digestion. In addition, confocal laser microscopic analysis had shown that HB4C5 cells incorporated a lot of histone but other cell lines did not incorporate it as much. These facts strongly suggest that histone acts as an immunoglobulin production-stimulating factor (IPSF) after internalization into the human B cell lines and the native structure of histone is required for the IPSF activity.
- 社団法人日本農芸化学会の論文
- 2002-06-23
著者
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SUGAHARA Takuya
Faculty of Agriculture, Ehime University
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Yamada Koji
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Okamoto Takeaki
Kawasaki Medical University
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Sugahara Takuya
Faculty Of Agriculture Ehime University
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Okamoto Takeaki
Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Tachibana Hirofumi
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Tachibana Hirofumi
Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Sugahara Takuya
Fac. Of Agriculture Ehime Univ.
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Yamada Koji
Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Yamada Koji
Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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