Oral administration of paraquat perturbs immunoglobulin productivity in mouse
スポンサーリンク
概要
- 論文の詳細を見る
Paraquat is one of the most widely used herbicides in the world and has been known to injure lungs, liver and skin in animals and human. Hence, it is important to understand the manner of paraquat in mammals. We studied the effect of paraquat on the immune function of mouse in vitro and in vivo. When splenocytes were cultured in vitro with various concentrations of paraquat, IgA productivity was not affected while IgG and IgM productivity decreased. On the other hand, Oral administration of paraquat for 1, 2 or 3 weeks increased IgA level but decreased IgM levels in serum of mice. Similarly IgA productivity increased while IgM productivity decreased. These results suggest that paraquat perturbs the lymphocytes immunoglobulin productivity in an immunoglobulin class-dependent manner.
- 2010-04-01
著者
-
OKABE Masaaki
Faculty of Agriculture, Ehime University
-
NISHIMOTO Sogo
Faculty of Agriculture, Ehime University
-
SUGAHARA Takuya
Faculty of Agriculture, Ehime University
-
AKIYAMA Koichi
Faculty of Agriculture, Ehime University
-
KAKINUMA Yoshimi
Faculty of Agriculture, Ehime University
-
Okabe Masaaki
Faculty Of Agriculture Ehime University
-
Nishimoto Sogo
Faculty Of Agriculture Ehime University
-
Akiyama Koichi
Faculty Of Agriculture Ehime University
-
Sugimoto Naoko
Faculty Of Agriculture Ehime University
-
Sugahara Takuya
Faculty Of Agriculture Ehime University
-
Kakinuma Yoshimi
Dep. Of Applied Bioresource Sci. Fac. Of Agriculture Ehime Univ.
-
Kakinuma Yoshimi
Faculty Of Agriculture Ehime University
-
Sugahara Takuya
Fac. Of Agriculture Ehime Univ.
-
Kakinuma Yoshimi
Faculty Agri, Ehime Univ.
関連論文
- Proteose Peptone Fraction of Bovine Milk Depressed IgE Production in Vitro and in Vivo
- Oral administration of paraquat perturbs immunoglobulin productivity in mouse
- Immunostimulatory in vitro and in vivo effects of a water-soluble extract from kale
- Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe
- Immunostimulatory in Vitro and in Vivo Effects of a Water-Soluble Extract from Kale
- Atg22p, a Vacuolar Membrane Protein Involved in the Amino Acid Compartmentalization of Schizosaccharomyces pombe
- Vba2p, A Vacuolar Membrane Protein Involved in Basic Amino Acid Transport in Schizosaccharomyces pombe
- White Sorghum (Sorghum bicolor (L.) Moench) Bran Extracts Suppressed IgE Production by U266 Cells
- 3P-134 腸内連鎖球菌V型ATPaseの膜内在性サブユニット(NtpI)の発現と精製(分子モーター,第47回日本生物物理学会年会)
- 2P-188 腸球菌ナトリウム輸送性V型ATPaseの膜内在性ローターリングのエンジニアリング(分子モーター(2),第46回日本生物物理学会年会)
- 1P-144 腸内連鎖球菌V型ATPaseの外周ストークのサブユニット構成とその溶液構造(分子モーター(1),第46回日本生物物理学会年会)
- Antifungal Activity of Morinol B Derivatives of Tetrahydropyran Sesquilignan
- Heavy oil fractions induce negative influences on mouse immune system
- Tributyltin induces Yca1p-dependent cell death of yeast Saccharomyces cerevisiae
- Severe abnormalities in the reproductive organs of mice caused by chemical substances contained in heavy oil
- Antimicrobial Activity of Stereoisomers of Morinols A and B, Tetrahydropyran Sesquineolignans
- Stereoselective Construction of Tetra-Substituted Tetrahydrofuran Compounds from Benzylic Hemiacetal in the Presence of H2 and a Pd Catalyst: Stereoselective Synthesis of a Stereoisomer of (−)-Virgatusin and Its Antimicrobiological Activity
- Immunostimulation Effect of Jellyfish Collagen
- Antibacterial Activity of a Virgatusin-Related Compound
- Antifungal Activity of Tetra-Substituted Tetrahydrofuran Lignan, (−)-Virgatusin, and Its Structure-Activity Relationship
- Antimicrobiological Activity of Lignan: Effect of Benzylic Oxygen and Stereochemistry of 2,3-Dibenzyl-4-butanolide and 3,4-Dibenzyltetrahydrofuran Lignans on Activity
- Effect of Benzylic Oxygen on the Cytotoxic Activity for Colon 26 Cell Line of Phenolic Lignans
- Radical and Superoxide Scavenging Activities of Matairesinol and Oxidized Matairesinol
- Tributyltin sensitivity of vacuolar-type Na^+-transporting ATPase from Enterococcus hirae
- Absolute Configuration of Volicitin from the Regurgitant of Lepidopteran Caterpillars and Biological Activity of Volicitin-Related Compounds
- The Effect of Secoisolariciresinol on 3T3-L1 Adipocytes and the Relationship between Molecular Structure and Activity
- Mode of Action of the Immunostimulatory Effect of Collagen from Jellyfish
- Deletion Analysis of the Subunit Genes of V-Type Na^+-ATPase from Enterococcus hirae
- Identification of Nucleotide Binding Sites in V-Type Na^+-ATPase from Enterococcus hirae
- Indispensable Glutamic Acid Residue-139 of NtpK Proteolipid in the Reaction of Vacuolar Na^+-Translocating ATPase in Enterococcus hirae
- Properties of the V_0 V_1 Na^+-ATPase from Enterococcus hirae and Its V_0 Moiety
- Isolation of Enterococcus hirae Mutant Deficient in Low-affinity Potassium Uptake at Alkaline pH(Microbiology & Fermentation Technology)
- Potassium/Proton Antiport System Is Dispensable for Growth of Enterococcus hirae at Low pH
- NapA Na^+/H^+ Antiporter as a Sodium Extrusion System Supplementary to the Vacuolar Na^+-ATPase in Enterococcus hirae
- Enhanced Sequence Coverage in Tryptic Fragment Analysis by Two-Dimensional HPLC/MS Using a Monolithic Silica Capillary Column
- First Stereoselective Synthesis of meso-Secoisolariciresinol and Comparison of Its Biological Activity with (+) and (−)-Secoisolariciresinol
- Immunomodulatory Effect of (−)-Matairesinol in Vivo and ex Vivo
- Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe
- Inhibition of the Discoloration of Yellowtail Dark Muscle by Lignan
- IgE-Suppressive Activity of (-)-Matairesinol and Its Structure-Activity Relationship
- Antifungal Activity of Morinol B Derivatives of Tetrahydropyran Sesquilignan
- Antimicrobial Activity of Stereoisomers of Butane-Type Lignans
- Inhibition of the Discoloration of Yellowtail Dark Muscle by Lignan
- Syntheses and Antimicrobial Activity of Tetrasubstituted Tetrahydrofuran Lignan Stereoisomers
- Antimicrobial Activity of Stereoisomers of Morinols A and B, Tetrahydropyran Sesquineolignans
- The Effect of Secoisolariciresinol on 3T3-L1 Adipocytes and the Relationship between Molecular Structure and Activity
- Antioxidant Activity of Butane Type Lignans, Secoisolariciresinol, Dihydroguaiaretic Acid, and 7,7'-Oxodihydroguaiaretic Acid
- Syntheses of All Stereoisomers of Goniodiol from Yeast-Reduction Products and Their Antimicrobiological Activity
- Structure-Antibacterial Activity Relationship for 9-O,9'-O-Demethyl (+)-virgatusin
- Stereoselective Construction of Tetra-Substituted Tetrahydrofuran Compounds from Benzylic Hemiacetal in the Presence of H_2 and a Pd Catalyst : Stereoselective Synthesis of a Stereoisomer of (-)-Virgatusin and Its Antimicrobiological Activity
- First Stereoselective Synthesis of meso-Secoisolariciresinol and Comparison of Its Biological Activity with (+) and (-)-Secoisolariciresinol
- Antimicrobiological Activity of Lignan : Effect of Benzylic Oxygen and Stereochemistry of 2,3-Dibenzyl-4-butanolide and 3,4-Dibenzyltetrahydrofuran Lignans on Activity
- Antifungal Activity of Tetra-Substituted Tetrahydrofuran Lignan, (-)-Virgatusin, and Its Structure-Activity Relationship
- Antibacterial Activity of a Virgatusin-Related Compound
- A Simple and Specific Procedure to Permeabilize the Plasma Membrane of Schizosaccharomyces pombe
- Vba2p, A Vacuolar Membrane Protein Involved in Basic Amino Acid Transport in Schizosaccharomyces pombe
- Improved Syntheses of Morinol C and D by Employing Mizoroki-Heck Reaction and Their Cytotoxic and Antimicrobial Activities
- Proteose Peptone Fraction of Bovine Milk Depressed IgE Production in Vitro and in Vivo
- Mode of Action of the Immunostimulatory Effect of Collagen from Jellyfish
- Use of the Benzyl Mesylate for the Synthesis of Tetrahydrofuran Lignan: Syntheses of 7,8-trans, 7′,8′-trans, 7,7′-cis, and 8,8′-cis-Virgatusin Stereoisomers
- Gene Transfection into HeLa Cells by Vesicles Containing Cationic Peptide Lipid
- Heavy oil fraction induces the dysplastic sperm in male mouse
- Vacuolar Amino Acid Transporter Avt5p Is Responsible for Lithium Uptake in Schizosaccharomyces pombe
- Atg22p, a Vacuolar Membrane Protein Involved in the Amino Acid Compartmentalization of Schizosaccharomyces pombe
- Heavy oil fraction induces the dysplastic sperm in male mouse
- Inhibition of myotube formation by paraquat in the myoblast cell line C2C12
- Immunostimulatory in Vitro and in Vivo Effects of a Water-Soluble Extract from Kale
- White Sorghum (Sorghum bicolor (L.) Moench) Bran Extracts Suppressed IgE Production by U266 Cells
- Increase of Immunoglobulin Productivity of Human-Human Hybridoma HB4C5 Cells by Histone(Biochemistry & Molecular Biology)
- Immunomodulatory Effect of (-)-Matairesinol in Vivo and ex Vivo
- Immunostimulation Effects of Yellowtail Heart Extracts in Vitro and in Vivo
- Effect of the Benzylic Structure of Lignan on Antioxidant Activity
- Disruption of Ion Homeostasis by Verrucosin and a Related Compound
- Sodium ATPase and Sodium/proton Antiporter Are Not Obligatory for Sodium Homeostasis of Enterococcus hirae at Acid pH
- Heavy oil fraction induces the dysplastic sperm in male mouse
- High IgM Production by Human-human Hybridoma HB4C5 Cells Cultured in Microtubes(Microbiology & Fermentation Technology)