Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe
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概要
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ATP-binding cassette (ABC) transporter plays an important role for resistance against xenobiotics. There are eleven ABC transporter genes in the genome of fission yeast Schizosaccharomyces pombe. We examined the role of ABC transporter against the toxicity of tributyltin chloride (TBT), a widespread environmental pollutant, in cell growth. Among individual ABC transporter mutants, the growth of a mutant deficient in Bfr1p, a plasma membrane-embedded transporter, was extremely sensitive to TBT. The lethal TBT concentration inducing 50% of cell death (LC50) was 25 µM for the parent strain and 10.2 µM for the bfr1∆ mutant. Thus, Bfr1p was responsible for TBT resistance in S. pombe.
著者
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SUGAHARA Takuya
Faculty of Agriculture, Ehime University
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NISHIMOTO Sogo
Center for Marine Environmental Studies, Ehime University
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Nishimoto Sogo
Faculty Of Agriculture Ehime University
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Akiyama Koichi
Faculty Of Agriculture Ehime University
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Akiyama Koichi
Integrated Center For Sciences Tarumi Station Ehime Univ.
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Sugimoto Naoko
Faculty Of Agriculture Ehime University
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KAWANO Miyuki
Integrated Center for Sciences (INCS), Ehime University
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Iwaki Tomoko
Faculty of Agriculture, Ehime University
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Chardwiriyapreecha Soracom
Faculty of Agriculture, Ehime University
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Sekito Takayuki
Faculty of Agriculture, Ehime University
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Kakinuma Yoshimi
Integrated Center for Sciences (INCS), Ehime University
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