Lowering Effect of an Isoflavone-Rich Fermented Soybean Extract on the Serum Cholesterol Concentrations in Female Rats, with or without Ovariectomy, but Not in Male Rats
スポンサーリンク
概要
- 論文の詳細を見る
We examined the effect of administering an isoflavone-rich fermented soybean extract (FSBE) on the serum cholesterol concentrations in male rats and in intact and ovariectomized (OVX) female rats. Dietary FSBE decreased the serum cholesterol concentrations in intact female and OVX rats, but did not affect the concentrations in male rats. Dietary FSBE increased the hepatic total and esterified cholesterol contents in the intact female rats, but decreased them in the OVX rats. This hypocholesterolemic effect was not a simple estrogenic effect because it has appeared in some reports that estrogen administration decreased serum cholesterol both male and female rats. Dietary FSBE increased the hepatic low-density lipoprotein receptor (LDLR) gene expression in the intact female rats as has previously been reported from many studies, but did not affect that of the OVX rats. Further investigation is needed into the hypocholesterolemic mechanism of FSBE.
- 社団法人 日本農芸化学会の論文
- 2006-07-23
著者
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Izumi T
The Department Of Hematology
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OBATA Akio
Research and Development Division, Kikkoman Corporation
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KISHIDA Taro
Department of Applied Bioscience, Faculty of Agriculture, Ehime University
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EBIHARA Kiyoshi
Department of Applied Bioscience, Faculty of Agriculture, Ehime University
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Obata A
Kikkoman Corp. Chiba Jpn
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Obata Akio
Research & Development Division Kikkoman Corporation
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Kishida Taro
Department Of Applied Bioscience Faculty Of Agriculture Ehime University
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Izumi Tohru
Research And Development Division Kikkoman Corporation
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MIZUSHIGE Takafumi
Department of Biological Resources, Faculty of Agriculture, Ehime University
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NAGAMOTO Manabu
Department of Biological Resources, Faculty of Agriculture, Ehime University
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OHTSU Yohhei
Department of Biological Resources, Faculty of Agriculture, Ehime University
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Ohtsu Yohhei
Department Of Biological Resources Faculty Of Agriculture Ehime University
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Nagamoto Manabu
Department Of Biological Resources Faculty Of Agriculture Ehime University
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Izumi Tohru
Department Of Cardiology And Internal Medicine Kitasato University
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Mizushige Takafumi
Department Of Applied Bioscience Faculty Of Agriculture Ehime University:(present Address)laboratory
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Kishida Taro
Fac. Of Agriculture Ehime Univ.
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Ebihara Kiyoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Ehime University
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