Inhibitory Effects of Soy Isoflavones on Cardiovascular Collagen Accumulation in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Oxidative stress is a major cause of cardiovascular tissue fibrosis. We evaluated the effects of daily doses of soy isoflavones, genistein and daidzein on cardiovascular tissue fibrosis in Otsuka Long-Evans Tokushima Fatty (OLETF) diabetic rats and Long-Evans Tokushima Otsuka (LETO) non-diabetic rats as a severe or mild oxidative stress model, respectively. Glucose and lipid metabolisms did not improve with genistein or daidzein treatment. However, genistein decreased hydroxyproline concentrations in the heart. Hydroxyproline reductions as a result of genistein were mildly stronger than those of daidzein. Thus, genistein significantly suppressed the progression of myocardial fibrosis in LETO rats despite the insignificant changes in OLETF rats. Although a daily dosage of isoflavone was not sufficient to prevent tissue fibrosis under marked oxidative stress in the early stage of diabetes, isoflavones might promise significant clinical benefits by reducing oxidative stress in the heart during aging.
- 日本ビタミン学会の論文
著者
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KISHIDA Taro
Department of Applied Bioscience, Faculty of Agriculture, Ehime University
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EBIHARA Kiyoshi
Department of Applied Bioscience, Faculty of Agriculture, Ehime University
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Kishida Taro
Department Of Applied Bioscience Faculty Of Agriculture Ehime University
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Miyatake Akira
Research Equipment Center Kagawa University School Of Medicine
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MIZUSHIGE Takafumi
Department of Biological Resources, Faculty of Agriculture, Ehime University
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MIZUSHIGE Katsufumi
Cardiology Division, Takamatsuhigashi National Hospital
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Mizushige Katsufumi
Cardiology Division Takamatsuhigashi National Hospital
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Mizushige Takafumi
Department Of Applied Bioscience Faculty Of Agriculture Ehime University:(present Address)laboratory
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Kishida Taro
Fac. Of Agriculture Ehime Univ.
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Ebihara Kiyoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Ehime University
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Mizushige Takahumi
Department of Applied Bioscience, Faculty of Agriculture, Ehime University
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