Studies on the fate of D-aspartic acid in pineal and pituitary glands of rats after intravenous administration

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The present study was intended to confirm the idea that D-aspartic acid (Asp) in pineal and pituitary glands could originate from diet as suggested by our previous report [Imai et al. (1997) Proc. Japan Acad. 73B, 48-52]. When the rats were kept under fasting for 2 or 3 days, the levels of D-Asp, but not L-Asp in these glands were significantly lower as compared with those in the rats with diet. The fact suggests that D-Asp in these glands is derived from the exogenous origin. Next, we determined the D- or L-Asp concentration in these glands (at 30min, 3hr and 24hr) and plasma (2min-5hr) following intravenous administration of D- or L-Asp (50mg/kg) into rats. D-Asp concentrations remarkably increased after administration of D-Asp, and the levels were almost constant from 30min to 24hr after administration, indicating that D-Asp was accumulated and deposited in these glands. In contrast, no accumulation of L-Asp was observed in case of L-Asp or D-Asp administration. In plasma, either D- or L-Asp concentration decreased to the normal level at 3hr after the administration of the respective enantiomers, although different half-lives for D- and L-Asp in plasma were obtained; 7.84min for D- and 3.75min for L-Asp. These results indicate that D-Asp incorporated from extracellular fluids into pineal and pituitary glands is difficult to be metabolized and eliminated, and strongly support the idea that the D-Asp in these glands in vivo is derived from the exogenous source, such as dietary D-Asp.
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Studies on the fate of D-aspartic acid in pineal and pituitary glands of rats after intravenous administration

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