POTENTIATION OF CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY BY THINNER INHALATION

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概要

• 論文の詳細を見る

• The interaction of thinner and carbon tetrachloride (CCl_4) induced hepatotoxicity was studied in the rats using the activity of plasma GOT and GPT, liver triglyceride and histopathologic changes of liver necrosis as indices. The animals were housed in a chamber with the continuous flow of thinner vapour (1.11 g/litre/hr) for 2 hrs prior to i.p. administration of CCl_4 (0.1 ml/kg BW) at 18 hrs after thinner inhalation. Thinner inhalation potentiated CCl_4 induced hepatotoxicity in a dosedependent manner. The maximal enhanced effect was observed at 24 hrs after CCl_4 administration by which the activities of PGOT and PGPT were significantly increased (3 folds). Thinner itself caused an additive effect on CCl_4 induced liver triglyceride accumulation. At 18 hrs after thinner inhalation, the activity of NADPH cytochrome C reductase was markedly increased (2.2 folds) but no change in the activity of aminopyrine N-demethylase which was able to increase the ^<14>・CCl_3 free radicals and binding to both the hepatic microsomal proteins (1.8 folds) andlipids (1.4 folds). In addition, thinner pretreatment somehow increased hepatic lipid peroxidation by 1.4 folds. These results suggest that thinner pretreatment causes an increase in mixed function oxidases to activate the formation of ・CCl_3 free radicals and binding to the microsomal proteins and lipids, which in turn stimulate hepatic damage via lipid peroxidation in the membrane.

• 日本トキシコロジー学会の論文
• 1990-05-25

著者

• GLINSUKON Thirayudh

  Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University

• Toskulkao Chaivat

  Department Of Physiology Faculty Of Science Mahidol University

• Glinsukon Thirayudh

  Department Of Physiology Faculty Of Science Mahidol University

• NHONGSAENG Jintanaporn

  Department of Physiology, Faculty of Science, Mahidol University

• Nhongsaeng Jintanaporn

  Department Of Physiology Faculty Of Science Mahidol University

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• Hepatic Lipid Peroxidation and Intracellular Calcium Accumulation in Ethanol Potentiated Aflatoxin B_1 Toxicity
• POTENTIATION OF CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY BY THINNER INHALATION
• ENDURANCE EXERCISE AND MUSCLE DAMAGE: RELATIONSHIP TO LIPID PEROXIDATION AND SCAVENGING ENZYMES IN SHORT AND LONG DISTANCE RUNNERS

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