Embryonic mortality and intrauterine growth retardation (IUGR) associated with placental alterations in pregnant rats treated with methyl methanesulfonate (MMS) at the peri-implantation stage
スポンサーリンク
概要
- 論文の詳細を見る
Embryonic mortality and intrauterine growth retardation (IUGR) are induced by exposure of rodents to xenobiotic agents during the pregastrulation period of development. We examined the time course of the effects of methyl methanesulfonate (MMS), an alkylating agent, on conceptus development in order to clarify the relative roles of the embryo and the placenta in their induction. Pregnant rats were treated orally with a single dose of MMS (200mg/kg) in the morning of gestation day (GD) 6 (peri-implantation stage). Embryonic mortality was increased on GD 12 and thereafter by MMS treatment, with newly dead embryos showing placental hypoplasia at GD 12. Embryo or fetal weight was also smaller for MMS-treated dams than for control dams from GD 14 to GD 20. The labyrinth zone and junctional zone (JZ) of the placenta were thinner in MMS-treated rats from GD 12 to GD 17 and from GD 12 to GD 20 (except for GD 17), respectively. Furthermore, MMS-treated dams showed a smaller number of glycogen cells in the JZ on GD 14. In contrast, the placental glycogen concentration was higher and the expression of glucose transporter 1 in the JZ remained at GD 20. These results indicate that exposure of pregnant rats to MMS at the peri-implantation stage of embryogenesis affects placental development and growth. The placental impairment induced by MMS was likely responsible for the embryonic death observed 6 days after exposure of dams to this agent as well as for the IUGR of surviving embryos or fetuses throughout the gestation period.
- 日本トキシコロジー学会の論文
- 2008-12-01
著者
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KAGAMI Hiroshi
Faculty of Agriculture, Shinshu University
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ONO Tamao
Faculty of Agriculture, Shinshu University
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TAMURA Toru
Division of Pathology, National Institute of Health Sciences
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Tamura Toru
キッセイ薬品工業中央研究所
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Tamura Toru
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Tamura Toru
信州大学 大学院総合工学系研究科
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KURODA Junji
Toxicology Laboratory, Kissei Pharmaceutical Co., Ltd.
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Ono Tamao
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Kagami Hiroshi
Fac. Of Agriculture Shinshu Univ. Jpn
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Kagami Hiroshi
Faculty Of Agriculture Shinshu University
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KOBAYASHI Kazuo
Toxicology Research Laboratory, R&D, Kissei Pharmaceutical Co., Ltd.
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Ono Tamao
Faculty Of Agriculture Shinshu University
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Kusama Hiroshi
Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.
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Kusama Hiroshi
Toxicology Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Kusama Hiroshi
Department Of Development Research Kissei Pharmaceutical Co. Ltd.
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Hayashi Morimichi
Toxicology Research Laboratory, R & D, Kissei Pharmaceutical Co., Ltd.
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Yokoi Ryohei
Interdisciplinary Graduate School of Science and Technology, Shinshu University
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Hayashi Morimichi
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Yokoi Ryohei
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Kuroda Junji
Toxicology Lab. Kissei Pharmaceutical Co. Ltd.
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Kuroda J
Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.
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Kuroda Junji
Toxicology
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Kusama Hiroshi
キッセイ薬品工業安全性研究所
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Hayashi Morimichi
Toxicology Laboratories Research And Development Kissei Pharmaceutical Co. Ltd.
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Kuriyama Kazuya
Toxicology Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Kasahara Hiroko
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Kobayashi Kazuo
Pharmacodynamics Research Laboratories Sankyo Co. Ltd.
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Tamura Toru
Div. Of Pathology Nihs
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Kobayashi Kazuo
Toxicology Research Laboratory, R & D, Kissei Pharmaceutical Co., Ltd.
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KOBAYASHI Kazuo
Toxicology Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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