Tranilast Suppresses the Disease Development of the Adjuvant-and Streptococcal Cell Wall-Induced Arthritis in Rats
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概要
- 論文の詳細を見る
This study explores the effects of the anti-allergic and anti-fibrotic agent tranilast on adjuvant- and streptococcal cell wall-induced arthritis in rats, animal models of rheumatoid arthritis in humans. Tranilast (150 or 300 mg/kg, twice daily) or vehicle only was administered orally to the two arthritis models, from 17 days before sensitization. As a comparative control, methotrexate (0.1 mg/kg, once daily) was given to another group. Tranilast suppressed the increase in foot volumes, paw thicknesses, clinical scores, and histopathological scores of the ankle joints in both models dose-dependently. In addition, the fibrosis indices of the ankles were dramatically decreased by tranilast in both of the models. Compared to the effects of methotrexate, tranilast seemed to work more effectively in the streptococcal cell wall-induced arthritis model than in the adjuvant-induced arthritis model. From these observations, it can be concluded that tranilast suppresses the development of arthritis in multiple models and is potentially a novel therapeutic agent for human rheumatoid arthritis.
- 社団法人 日本薬理学会の論文
- 2007-09-20
著者
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TAMURA Toru
Division of Pathology, National Institute of Health Sciences
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Tamura Toru
キッセイ薬品工業中央研究所
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Tamura Toru
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Tamura Toru
信州大学 大学院総合工学系研究科
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Nakayama Jun
Department of Clinical Medicine, Shinshu University, School of Medicine
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SHIBATA Nobuo
Research and Development Division, Kissei Pharmaceutical Co. Ltd.
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Kuroda Junji
Toxicology Lab. Kissei Pharmaceutical Co. Ltd.
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Kuroda J
Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.
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Kuroda Junji
Toxicology
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NAGATE Toshiaki
Department of Pathology, Shinshu University School of Medicine
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TAMURA Toru
Development Research Department, R&D, Kissei Pharmaceutical Co., Ltd.
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SATO Fumiyasu
Development Research Department, R&D, Kissei Pharmaceutical Co., Ltd.
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KURODA Junji
Development Research Department, R&D, Kissei Pharmaceutical Co., Ltd.
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SHIBATA Nobuo
Development Research Department, R&D, Kissei Pharmaceutical Co., Ltd.
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Sato Fumiyasu
Development Research Department R&d Kissei Pharmaceutical Co. Ltd.
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Shibata Nobuo
Research And Development Division Kissei Pharmaceutical Co. Ltd.
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Shibata Nobuo
Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.
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Nagasawa Tatsuya
Department Of Pathology Shinshu University School Of Medicine
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Shibata Nobuo
Development Research Department R&d Kissei Pharmaceutical Co. Ltd.
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Nakayama Jun
Department Of Clinical Medicine Shinshu University School Of Medicine
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Tamura Toru
Div. Of Pathology Nihs
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