Pulmonary Lymphoepithelioma-like Carcinoma : Predominant Infiltration of Tumor-associated Cytotoxic T Lymphocytes Might Represent the Enhanced Tumor Immunity
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概要
- 論文の詳細を見る
Lymphoepithelioma-like carcinoma (LELC) of the lung is an undifferentiated carcinoma with prominent lymphoid stroma. We encountered a case of synchronous primary lung cancers of LELC and papillary adenocarcinoma in a 67-year-old Japanese woman. By in situ hybridization, Epstein-Barr virus (EBV) genome was detected in malignant epithelial cells of LELC but not in the papillary adenocarcinoma. Tumor-infiltrating lymphocytes in LELC were predominantly CD8+ and T cell intracytoplasmic antigen (TIA-1)+ cytotoxic T cells with closely associated with HLA-DR-positive LELC cells by double immunostaining. These data indicate that the exaggerated lymphoid infiltration in and around the EBV-infected carcinoma cells may represent the enhanced tumor immunity, suggesting a better prognostic indicator.
- 社団法人 日本内科学会の論文
- 2004-04-01
著者
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Nakayama Jun
Department of Clinical Medicine, Shinshu University, School of Medicine
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ITO Makoto
Laboratory of Marine Biochemistry, Faculty of Agriculture, Kyushu University
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Sano Kenji
Division Of Diagnostic Pathology Department Of Pathology And Laboratory Medicine Kariya General Hosp
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Nakayama Jun
Department Of Pathology Shinshu University School Of Medicine
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Honda Takayuki
Division Of Diagnostic Pathology Department Of Pathology And Laboratory Medicine Kariya General Hosp
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KOBAYASHI Motohiro
Department of Pathology, Shinshu University School of Medicine
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Nakayama Jun
Department Of Clinical Medicine Shinshu University School Of Medicine
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Kobayashi Motohiro
Department Of Pathology Shinshu University School Of Medicine
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Ito Makoto
Department Of Pathology And Laboratory Medicine Kariya General Hospital
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Sano Kenji
Division Of Diagnostic Pathology Department Of Pathology And Laboratory Medicine Kariya General Hosp
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Ito Makoto
Laboratory Medicine Shinshu University School Of Medicine
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Kobayashi Motohiro
Department of Molecular Pathology, Shinshu University Graduate School of Medicine
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