Role of Sulfated O-Glycans Expressed by High Endothelial Venule-Like Vessels in Pathogenesis of Chronic Inflammatory Gastrointestinal Diseases
スポンサーリンク
概要
- 論文の詳細を見る
Lymphocyte homing is mediated by a cascade of adhesive interactions between circulating lymphocytes and specialized endothelial cells comprising high endothelial venules (HEVs). Sulfated O-glycans expressed on HEVs, collectively called peripheral lymph node addressin (PNAd), interact with L-selectin expressed on lymphocytes, contributing to the initial step of the lymphocyte homing. In chronic inflammatory states, PNAd is induced on HEV-like vessels but absent in non-lymphoid tissues under normal conditions. Such HEV-like vessels have been observed in various chronic inflammatory diseases including rheumatoid arthritis, lymphocytic thyroiditis, Helicobacter pylori-associated chronic gastritis, and inflammatory bowel disease (IBD), and implicated in lymphocyte recruitment in those diseases. In H. pylori-associated chronic gastritis, PNAd-expressing HEV-like vessels are induced, and the progression of chronic inflammation is highly correlated with appearance of these vessels. Furthermore, eradication of H. pylori by antibiotics resulted in disappearance of PNAd. These results indicate that inhibition of PNAd formation could have therapeutic effect by attenuating lymphocyte recruitment. In ulcerative colitis (UC), PNAd-expressing HEV-like vessels are induced, preferentially in the active phase, and T cells, particularly CD4+ T cells, are closely associated with these vessels, suggesting that T cell recruitment via PNAd-expressing HEV-like vessels plays at least a partial role in UC pathogenesis. Additionally, N-acetylglucosamine-6-O-sulfotransferase 1 (GlcNAc6ST-1) is suggested to be a candidate to regulate PNAd induction on HEV-like vessels in UC. These results provide a potential therapeutic strategy to treat UC by blocking T cell adhesion to PNAd-expressing HEV-like vessels. Inhibition or down-regulation of GlcNAc6ST-1 may be an alternative.
著者
-
Nakayama Jun
Department Of Clinical Medicine Shinshu University School Of Medicine
-
Kobayashi Motohiro
Department Of Pathology Shinshu University School Of Medicine
-
NAKAYAMA Jun
Department of Molecular Pathology, Shinshu University Graduate School of Medicine
-
Fukuda Minoru
Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research
-
Kobayashi Motohiro
Department of Molecular Pathology, Shinshu University Graduate School of Medicine
関連論文
- Tumor Necrosis Factor (TNF) とInterleukin (IL)-1の直接注入による脳病変
- Non-thermal cytocidal effect of infrared irradiation on cultured cancer cells using specialized device
- A Rare Lung Nodule Consisting of Adenocarcinoma and Amyloid Deposition in a Patient with Primary Systemic AL Amyloidosis
- S1-3 Role of gland mucous cell-type mucin in the gastric mucosa infected with Helicobacter pylori(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- CT and MR Findings of a Pleomorphic Adenoma in the Peripheral Lung
- Ontogeny of the Rat Parietal Cell: Analysis Using Anti- parietal Cell Antibody and Transmission Electron Microscopy
- P-812 Enhanced Expression of Core 2 β -1,6-N-acetylglucosaminyltransferase (C2GnT) Gene in Human Lung Cancer
- Correlation between glial fibrillary acidic protein-positive astrocytes and age in the human hippocampus
- II-B-28 Increased expression of a vanilloid receptor, TRPV1 in rat stellate ganglia induced by inflammatory stimuli and its down regulation by RNA interference(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Tranilast Suppresses the Disease Development of the Adjuvant-and Streptococcal Cell Wall-Induced Arthritis in Rats
- Female adnexal tumor of probable wolffian origin : Morphological, immunohistochemical, and ultrastructural study with c-kit gene analysis
- Pulmonary Lymphoepithelioma-like Carcinoma : Predominant Infiltration of Tumor-associated Cytotoxic T Lymphocytes Might Represent the Enhanced Tumor Immunity
- Clinical utility of quantitative RT-PCR targeted to α1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer
- Identification of oligopeptides binding to peritoneal tumors of gastric cancer
- Liver Organogenesis from Murine Embryonic Stem Cells(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Application of Mucin Histochemistry for Pathological Diagnosis : Expression of Gastric Phenotypes in Metaplastic and Neoplastic Lesions and its Relation to the Organoid Differentiation
- Histo- and Cytochemistry of Gland Mucus Cell Type Mucin and Its Practical Application for Pathologic and Clinical Diagnosis
- Malignant myoepithelioma (myoepithelial carcinoma) of soft tissue
- The Utility of Formalin-fixed and Paraffin-embedded Tissue Blocks for Quantitative Analysis of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase mRNA Expressed by Colorectal Cancer Cells
- A Case of Ganglioneuroma with Fatty Replacement:CT and MRI Findings
- Histological diversity of vasculitic lesions in MPO-ANCA-positive autopsy cases
- A rat model of hypereosinophilic syndrome
- Role of Sulfated O-Glycans Expressed by High Endothelial Venule-Like Vessels in Pathogenesis of Chronic Inflammatory Gastrointestinal Diseases
- Therapeutic and Preventive Effects of Methotrexate on Zymosan-Induced Arthritis in SKG Mice
- Arachidonic Acid-Induced COX-1 and COX-2-Mediated Vasodilation in Rat Gingival Arterioles In Vivo
- IIB-10 Lymphangiogenesis occurred in colorectal carcinoma and its clinicopathological significance(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- S3-02 Application of immunohistochemistry for study of ASC-related molecules in diseases(Advanced Histochemistry)
- Immunohistochemical demonstration of apoptosis-regulated proteins, Bcl-2 and Bax, in resected non-small-cell lung cancers
- Spiral Cleavage of Mica
- Primary Malignant Sarcomatoid Mesothelioma in the Pericardium