Effects of Neopterin on the Hematopoietic Microenvironment of Senescence-Accelerated Mice (SAM)(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
The pteridine neopterin (NP) is produced by monocytes and is known to be a useful marker of immunological activation, although, it remains elusive whether neopterin itself exhibits biological functions. Recently, we found that NP stimulates hematopoietic cell proliferation and differentiation by activating bone marrow stromal cell function. In order to elucidate the biological effect of NP on stromal cells, its effects on hematopoiesis was determined in the mouse model of age-related stromal impairment, senescence-accelerated mice (SAMs). An intraperitoneal administration of NP increased the number of peripheral leukocytes and CFU-GM in the bone marrow and spleen of young SAMs, however, no increase of CFU-GM in old SAMs (stromal impairment) was observed when compared with young SAMs. NP also increased the CFU-GM colony formation of bone marrow and spleen cells from young SAMs in a soft agar culture system, but it did not enhance CFU-GM colony formation of cells from old SAMs cultured in this system. Treatment with NP induced the production of hematopoietic stimulating factors, including IL-6 and GM-CSF, by bone marrow stromal cells from young SAMs but stromal cells from old SAMs did not respond to NP stimulation. Further studies will be required to clarify the mechanism by which NP stimulates the production of hematopoietic growth factors from stromal cells, the results of this study indicate that NP is a potent hematopoietic regulatory factor by activating stromal cell function(s).
- 社団法人日本薬学会の論文
- 2006-01-01
著者
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AIZAWA Shin
Department of Functional Morphology, Nihon University School of Medicine
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INOUE Tohru
Division of Toxicology
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Aizawa Shin
Department Of Anatomy Nihon University School Of Medicine
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Inoue Tohru
Division Of Toxicol. Mutagen. Nihs
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KANBE Emiko
Department of Internal Medicine, Nihon University School of Medicine
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HATTA Yoshihiro
Department of Internal Medicine, Nihon University School of Medicine
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TSUBOI Isao
Department of Anatomy, Nihon University School of Medicine
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HARADA Tomonori
Department of Anatomy, Nihon University School of Medicine
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KOSHINAGA Morimichi
Department of Anatomy, Nihon University School of Medicine
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Tsuboi Isao
Department Of Anatomy Nihon University School Of Medicine
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Tsuboi Isao
The First Department Of Internal Medicine Nihon University School Of Medicine
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Kanbe Emiko
Department Of Internal Medicine Nihon University School Of Medicine:department Of Anatomy Nihon Univ
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Aikawa Shingo
Department Of Anatomy Nihon University School Of Medicine
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Hatta Yoshihiro
Department Of Internal Medicine Nihon University School Of Medicine
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Aikawa Shingo
The First Department Of Internal Medicine Nihon University School Of Medicine
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Hatta Yoshihiro
Department Of Hematology And Rheumatology Nihon University School Of Medicine
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Inoue Tohru
Division Of Cellular And Molecular Toxicology Center For Biological Safety And Research National Ins
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Koshinaga Morimichi
Department Of Anatomy Nihon University School Of Medicine
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Inoue Tohru
Division Of Cellular & Molecular Toxicology Center For Biological Safety Research National Insti
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Tsuboi Isao
Department Of Functional Morphology Nihon University School Of Medicine
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Harada Tomonori
Department Of Functional Morphology Nihon University School Of Medicine
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