Mast Cell Development and Biostresses: Different Stromal Responses in Bone Marrow and Spleen after Treatment of Myeloablater, 5-Fluorouracil, and Inflammatory Stressor, Lipopolysaccharide

スポンサーリンク

概要

• 論文の詳細を見る

• Mast-cell-development in the bone-marrow (BM) and the spleen is restrictedly controlled by stromal-cells which produce positive-regulators such as stem cell factor (SCF), and negative-regulators such as transforming growth factor-β (TGF-β). How the balance between positive- and negative-regulation is achieved or maintained by stromal-cells is not well understood. We intravenously injected 5-fluorouracil (5-FU) and lipopolysaccharide (LPS) into C3H/HeN mice to disrupt mast-cell-development in order to reveal mechanisms of mast-cell-regulation. 5-FU treatment induces a rapid decrease in the number of mast-cell-progenitor (colony-forming unit (CFU)-mast) cells in the BM and spleen, followed by rapid recovery of CFU-mast numbers. Expression of the SCF gene is one-fiftieth the level of that of TGF-β during the steady-state in BM and spleen. After 5-FU treatment, SCF mRNA levels in the BM markedly increased, approaching TGF-β mRNA levels, whereas SCF levels in the spleen showed limited oscillations whose increases paralleled those in TGF-β levels. In contrast, LPS treatment induces a rapid decrease in CFU-mast number in the BM and a rapid increase in of CFU-mast number in the spleen. After LPS treatment, SCF mRNA levels in the BM markedly decreased, whereas SCF levels in the spleen remained unchanged. These results suggest that regulation of mast-cell-development is dominated by negative-signals in the BM and spleen during the steady-state, and, under biostress-conditions such as 5-FU and LPS treatment, the balance between positive- and negative-regulation can be changed in the BM but not in the spleen. The difference in the regulation of mast-cell-development in the BM versus the spleen probably reflects the different roles of tissue-specific stromal-cells.

著者

• Hirabayashi Yoko

  Division Of Cellular And Molecular Toxicology Kangwon National University

• Aizawa Shin

  Department Of Anatomy Nihon University School Of Medicine

• HARADA Tomonori

  Department of Anatomy, Nihon University School of Medicine

• Tsuboi Isao

  Department Of Anatomy Nihon University School Of Medicine

• Oshima Hideki

  Department Of Neurological Surgery Nihon University School Of Medicine

• Kanno Jun

  Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute

• Inoue Tohru

  Department Of Chemistry Faculty Of Science Fukuoka University

• Hokari Takeo

  Department of Functional Morphology, School of Medicine, Nihon University

• Oshima Hideki

  Department Of Cardiac Surgery Nagoya University Graduate School Of Medicine

• Hirabayashi Yoko

  Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Science

• Kanno Jun

  Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Science

• Aizawa Shin

  Department of Functional Morphology, School of Medicine, Nihon University

• Tsuboi Isao

  Department of Functional Morphology, School of Medicine, Nihon University

• Inoue Tohru

  Department of Functional Morphology, School of Medicine, Nihon University

• Harada Tomonori

  Department of Functional Morphology, School of Medicine, Nihon University

関連論文

• Stromal cells in bone marrow play important roles in pro-inflammatory cytokine secretion causing fever following bortezomib administration in patients with multiple myeloma
• Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain
• Enigma of oxidative stress in benzene induced hematotoxicity answered by thioredoxin-overexpression mouse(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
• A SURVEY OF THE VALUES OF CLINICAL CHEMISTRY PARAMETERS OBTAINED FOR A COMMON RAT BLOOD SAMPLE IN NINETY-EIGHT JAPANESE LABORATORIES
• Comparison of the early gene responses of Ahr-activating chemicals using the Percellome system(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
• The development of Chemical Toxicogenomics Database by the "Percellome" system for the mechanism-based toxicology(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
• Bio-molecular model for cancer prevention : Attenuation of oxidative stress by thioredoxin over-expression to reduce the benzene leukemia (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Aryl hydrocarbon receptor (AhR) mediated hematotoxicity induced by benzene.(GENERAL SESSION BY ORAL PRESENTATION)(BLOOD SYSTEM & HEMATOLOGY)
• Induction of Dihydropyrimidine Dehydrogenase Expression by Mitomycin C in Colorectal Cancer
• Recording of Corticospinal Evoked Potential for Optimum Placement of Motor Cortex Stimulation Electrodes in the Treatment of Post-stroke Pain : Two Case Reports
• Urethral leiomyoma expressing estrogen receptors
• AN-P6 Effect of fibroblast cell which grew on amphiphilic polymer particle on the proliferation and differentiation of blood progenitor cell(Section I Animal and Plant Cell Cultures)
• Micelle Formation of Phosphate-Type Hybrid Surfactants in Aqueous Solution
• Effects of Neopterin on the Hematopoietic Microenvironment of Senescence-Accelerated Mice (SAM)(Molecular and Cell Biology)
• Increased Number of Hematopoietic Stem Cells in Adherent Layer of Bone Marrow Cell Culture with Stroma by Treatment with Granulocyte Colony-Stimulating Factor
• Efficient transformation of small hepatocytes into insulin-expressing cells by forced expression of Pdx1
• Hyperbaric oxygen stimulates cell proliferation and normalizes multidrug resistance protein-2 protein localization in primary rat hepatocytes
• Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model
• Letter to the Editor
• Response to Letter to the Editor(2)
• Response to Letter to the Editor(1)
• Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
• Construction of Model Mice which Have Humanized Immune System.
• Construction of Model Mice Which Have Humanized Immune System
• Temperature-Induced Phase Transitions in 1,3,5-Trimethylbenzene Crystal
• Primary aortic intimal sarcoma
• Type B aortic dissection associated with coarctation of the aorta
• P11-16 EFFECTS OF TCDD ON THE GENE EXPRESSION IN MOUSE EMBRYONIC STEM CELLS IN CULTURE
• ACUTE, SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-ISOBUTYLIDENEBIS (4,6-DIMETHYLPHENOL) IN RATS
• Analysis of the effect of dietary phytoestrogens on the gene expression profiles of endocrine disruptors using the "Percellome" system(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
• P7-35 Three-months dietary toxicity study of o-cymen-5-ol(biosol) in rats : Biosol induced renal injury and thymocyte apoptosis(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
• "P-12 The effects of 90-day feeding of Aramite or other herbicides of diphenyl ether group on livers, gall-bladders and bile ducts in dogs.
• Sample surveillance for clinical pathology testing.
• Efficacy of Photodynamic Therapy (PDT) Using Na-Pheophorbide α in a Murine Model of Experimental methicillin-resistant Staphylococcus aureus (MRSA) Arthritis
• Intrauterine environment-genome interaction and Children's development (2) : Brain structure impairment and behavioral disturbance induced in male mice offspring by a single intraperitoneal administration of domoic acid (DA) to their dams
• Gene expression profiling of a gene-targeted mouse embryo using the "Percellome" system as a model for molecular developmental toxicity(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
• Letter to the Editor(1)
• P12-03 Is Nrf2 gene Involved in benzene metabolic pathway?
• O-55 HEMATOTOXICICOLOGIC CHARACTERISTICS FOR OXIDATIVE STRESSES INTRANSGENIC AND/OR KNOCK-OUT MICE FOR THIOREDOXIN/ADF GENE.(Proceedings of the 27th Annual Meeting)
• 21B-10-4 Benzene hemopoietic toxicity revisited- a new concept.
• 3A-09 Hemopoietic Stem-Cell Kinetics Evaluated by Bromodeoxyuridine Incorporation Followed by Near-UV Exposure to Kill Cycling Stem Cells (BUUV). 2) Bone Marrow Cells from Mice Carrying Human c-myc Proto-Oncogene with Promoters Combined with Immunoglobuli
• "P-8 Experimental myelodysplasia induced by Azidothymidine (AZT) : Hemopoietic Stem Cell Kinetics And Pathological Findings.
• Sample surveillance for clinical pathology testing(2) Analysis of blood chemical data
• BLOOD OF RATS AND DOGS FOR USE AS SURVEILLANCE SAMPLES : INVESTIGATION OF STORAGE AND TRANSPORTATION CONDITIONS
• Infective Endocarditis with an Aortic Periannular Abscess Extending along the Right Coronary Artery
• Traumatic Cervical Internal Carotid Artery Occlusion in an Infant : Case Report
• Des-γcarboxy prothrombin (PIVKA-II) and α-fetoprotein producing gastric cancer with multiple liver metastases
• Sagittal Magnetic Resonance Imaging of Intramural Hematoma From Non-traumatic Dissection of the Anterior Cerebral Artery
• Drug challenge test and drip infusion of ketamine for post-stroke pain
• Morphological Change of Acidic and Neutral Liposomes Induced by Basic Amphiphilic α-Helical Pepties with Systematically Varied Hydrophobic Hydrophilic Balance
• Additional Bias Effects on the Formation of Amorphous Hydrogenated Carbon Films by ECR
• P10-07 BASIC PROPERTIES OF UTEROTROPIC RESPONSE.
• Mutational Inactivation of Mitotic Checkpoint Genes, hsMAD2 and hBUB1, Is Rare in Sporadic Digestive Tract Cancers
• p16^ Gene Mutations Are Relatively Frequent in Ampullary Carcinomas
• Frequent Somatic Mutations of the APC and p53 Genes in Sporadic Ampullary Carcinomas
• Mutational Analysis of the p53 and K-ras Genes and Allelotype Study of the Rb-1 Gene for Investigating the Pathogenesis of Combined Hepatocellular-Cholangiocellular Carcinomas
• EFFECTS OF TCDD ON THE GENE EXPRESSION IN MOUSE EMBRYONIC STEM CELLS IN CULTURE.(GENERAL SESSION BY POSTER PRESENTATION)(DEVELOPMENT AND REPRODUCTION)
• Gene Expression Profiling and Cellular Distribution of Molecules with Altered Expression in the Hippocampal CA1 Region after Developmental Exposure to Anti-Thyroid Agents in Rats
• Therapy-relatde Megakaryblastic Leukemia with Pituitary Involvement Following Treatment for Non-Hodgkin's Lymphoma
• Discoid lateral menisci in Japanese cadaver knees
• Changes of Differentiation and Proliferation in K562 Cells with Various Levels of Knockdown of Cationic Amino Acid Transporter 1
• Role of Polyamines Derived from Arginine in Differentiation and Proliferation of Human Blood Cells(Molecular and Cell Biology)
• Fullerene (C_) Is Negative in the In Vivo Pig-A Gene Mutation Assay
• Surface Tension Study on Aqueous Solution of Nonionic Surfactant with Unsaturated Hydrocarbon Chain
• Positive Expression of Macrophage Inflammatory Protein-1α and -1β in a Patient with Diffuse Large B-cell Lymphoma Accompanied by Hypercalcemia and Multiple Osteolysis
• Mast Cell Development and Biostresses: Different Stromal Responses in Bone Marrow and Spleen after Treatment of Myeloablater, 5-Fluorouracil, and Inflammatory Stressor, Lipopolysaccharide
• Serum-free culture of murine embryonic stem (ES) cells for the analysis of developmental toxicity(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
• Perinatal exposure to low dose diethylstilbestrol (DES) alters uterine response to prepubertal estrogen stimulation and induces multioocyte follicles in prepubescent CD-1 mice(Endocrine system, Proceedings of the 32nd Annual Meeting)
• A Percellome toxicogenomics study on the disruption of epigenetic regulation in neuronal stem cell model(Analysis of Toxicological Mechanisms : A Toxicogenomics Approach, Proceedings of the 32nd Annual Meeting)
• Additive Estrogenic Effect Of Genistein And Bisphenol A, And Anti-Estrogenic Effect Of (-)-Epigallocatechin Gallate In MCF-7 Cells.
• Overview: "Children's Toxicology", a renovating study field of irreversible "early exposure-delayed effects"
• P10-12 Astatistical analysis method for synergism using in vivo assay systems
• Rapid screening method of endocrine disrupting chemicals using surface plasmon resonance sensor (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• The Effect of Cation Vacancies on the Magnetic Annealing of Co_xFe_O_4
• CITED2 is activated in ulcerative colitis and induces p53-dependent apoptosis in response to butyric acid
• Isolated Cardiac Metastasis From Sacral Chordoma
• Electrical Conduction in Ti-TiO_2-Au Thin-Film Device
• Hepatoid carcinoma of the uterus that collided with carcinosarcoma
• Effect of Chain Length Distribution on Aqueous Phase Behavior of Polyethylene Glycol Alkyl Ethers
• Specific Heats of Copper Ferrite
• Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence
• Effect of Minocycline on Inflammatory Cell Reactions in Cerebral Contusion in Rats
• Pathogenesis of paravalvular leakage as a complication occurring in the late phase after surgery
• Procedural Risk and Long Term Outcome of Pacemaker System Removal by Using Cardio-Pulmonary Bypass
• Ovariectomized mouse uterotrophic assay of 36 chemicals
• Neuroethics of Deep Brain Stimulation for Mental Disorders : Brain Stimulation Reward in Humans
• Management of Localized Cardiovascular Implantable Electronic Device Pocket Infection without Lead Removal
• Response to Letter to the Editor(2)
• Effect of Hydrophilic Additives on Mesophase Regions of Aqueous Nonionic Surfactant Mixture
• Long-term results of the maze procedure in patients with mechanical valve
• Aggregation Behavior of Nonionic Surfactants in Room Temperature Ionic Liquids
• Kinetics for micelle-monomer association-dissociation reaction of surfactants with hydrophobic counterions.
• Effect of polyethylene glycol monoalkyl ethers on phase transition temperature of dipalmitoylphosphatidylcholine vesicle membrane.
• The influence of ureas on the phase-transition behavior of the dipalmitoylphosphatidylcholine vesicle membrane.
• Long-term results of tissue-engineered small-caliber vascular grafts in a rat carotid arterial replacement model
• The catalytic action of a mixed micelle of lauroylamino acid and a detergent.
• Oral administration of pentachlorophenol induces interferon signaling mRNAs in C57BL/6 male mouse liver

もっと見る 閉じる

スポンサーリンク