An Unstable Epoxy Intermediate Formed by the Microsomal Oxidation of 4-Nitrophenyl Vinyl Ether
スポンサーリンク
概要
- 論文の詳細を見る
An epoxy intermediate, 2-(4-nitrophenoxy)oxirane (NPO), previously proposed to be a shortlived intermediate in the microsomal metabolism of 4-nitrophenyl vinyl ether (NPVE), was isolated by high-performance liquid chromatography and identified by mass spectrometric comparison with an authentic specimen. NPO decomposed to glycolaldehyde and 4-nitrophenol with a half life of 4.6min in 0.1M phosphate buffer, pH7.4,at 37℃. The hydrolytic decomposition was accelerated by the addition of rat hepatic microsomes, but the accelerating effect was reduced by the addition of 3,3,3-trichloropropene oxide, a microsomal epoxide hydrolase inhibitor.These results indicate that NPO is an obligatory intermediate in the microsomal conversion of NPVE to glycolaldehyde and 4-nitrophenol.
- 社団法人日本薬学会の論文
- 1988-06-25
著者
-
磯部 正和
摂南大・薬・毒性
-
高畠 英伍
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
-
高畠 英伍
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
-
曽根 知道
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
-
磯部 正和
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
-
曽根 知道
摂南大・薬・毒性学
-
Takabatake E
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
関連論文
- オーファン・ドラッグとしてのサリドマイドの復活
- Partial Purification and Substrate Specificity of Flavin-Containing Monooxygenase from Rat Brain Microsomes
- Determination of Flavin-Containing Monooxygenase Activity in Rat Brain Microsomes with Benzydamine N-Oxidation
- 環境中ベリリウムの動態に関する研究大気中ベリリウム及びストロンチウムの挙動について
- TRIMETHADIONE TOLERANCE TEST FOR EVALUATION OF FUNCTIONAL RESERVE OF THE LIVER IN PATIENTS WITH LIVER CIRRHOSIS AND ESOPHAGEAL VARICES
- THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
- Purification and Characterization of Hamster Hepatic Microsomal N, O-Acetyltransferase
- モルモット肝カルボキシルエステラーゼ分子種の性状について
- ラットform 2 typeカルボキシルエステラーゼ遺伝子の構造解析
- ラット肝ミクロソームのフェノバルビタールにより誘導されるカルボキシルエステラーゼのcDNAクローニングと発現
- 肝カルボキシルエステラーゼ活性に必須なアミン酸残基のSite-specific Mutagenesis法による同定
- ヒト肝カルボキシルエステラーゼ分子種のcDNAクローニングとCOS細胞での発現
- ラット肝ミクロソーム画分のform 2 typeカルボキシルエステラーゼの精製と性質
- 肝カルビキシルエステラーゼ活性に必須なアミノ酸残基のSite-specific Mutagenesis法による同定
- Effect of Ring Substituent on the Stability of the Epoxide Derived from Phenyl Vinyl Ether
- An Unstable Epoxy Intermediate Formed by the Microsomal Oxidation of 4-Nitrophenyl Vinyl Ether
- Comparison of Properties of Human Intestinal and Placental Alkaline Phosphatase
- Purification of Human Intestinal Alkaline Phosphatase
- The Role of Epoxides in the Metabolic Activation of Styrene to Mutagens (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
- The Reaction of S-Acylthiamine and 2-Mercaptoethanol
- 薬学教育における薬剤師教育
- 薬物の経皮吸収におけるレシチンの効果(第2報)ゲル軟膏からのインドメタシンの経皮吸収に対するレシチンの促進効果の機構
- 薬物の経皮吸収におけるレシチンの効果(第1報)インドメタシンゲル軟膏のラット背部経皮吸収と排泄
- ABSORPTION AND EXCRETION OF INDOMETHACIN GEL OINTMENT CONTAINING EGG LECITHIN
- Modification of Drug-Metabolizing Enzyme Activity of Rats in Carrageenin-Inflammation
- The Effect of AF2 [2-(2-Furyl)-3-(5-nitro-2-furyl) acrylamide] on Hepatic Microsomal Mixed Function Oxidase System in Rats
- Metabolism of Benzydamine Hydrochloride
- Comparative N-Demethylation of Antihistaminic Agents possessing Dimethylaminoalkyl Group by Liver Preparations from Four Animal Species
- The Inductive Effect of Mepirizole on the Drug Metabolizing Enzymes of Rat Liver
- The Metabolic Fate of 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (Mepirizole, DA-398) in Rats and Rabbits
- 発癌性芳香族アミドを代謝活性化する肝ミクロソ-ムN,O-アセチル転移酵素に関する研究
- STUDIES ON METABOLISM AND TOXICITY OF STYRENE. II. MUTAGENESIS IN SALMONELLA TYPHIMURIUM BY METABOLIC ACTIVATION OF STYRENE WITH 3-METHYLCHOLANTHRENE PRETREATED RAT LIVER
- STUDIES ON METABOLISM AND TOXICITY OF STYRENE. I. BIOTRANSFORMATION OF STYRENE TO STYRENE GLYCOL VIA STYRENE OXIDE BY RAT LIVER MICROSOMES
- The Metabolism and Excretion of Trimethadione in Patients with Percutaneous Transhepatic Biliary Drainage and Renal Dysfunction
- Sex-Related Differences in Hepatic Drug-Oxidizing Capacity of Streptozotocin-Induced Diabetic Rats
- TRIMETHADIONE METABOLISM IN PATIENTS WITH NORMAL LIVER AND IN PATIENTS WITH CHRONIC LIVER DISEASE
- HEPATIC TRIMETHADIONE-OXIDIZING CAPACITY REMAINS NORMAL IN PATIENTS WITH EXTRAHEPATIC CHOLELITHIASIS
- Effects of Mushroom Toxins on Glycogenolysis : Comparison of Toxicity of Phalloidin, α-Amanitin and DL-Propargylglycine in Isolated Rat Hepatocytes
- EFFECTS OF CIMETIDINE AND DIETHYLAMINOETHYL 2,2-DIPHENYLVALERATE HCL (SKF 525-A) ON TRIMETHADIONE METABOLISM IN THE RAT