In Vitro Inhibitory Effects of Pulvinic Acid Derivatives Isolated from Chinese Edible Mushrooms, Boletus calopus and Suillus bovinus, on Cytochrome P450 Activity
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概要
- 論文の詳細を見る
Increasing attention has been focused on food-drug interactions. We have investigated the inhibitory effect of Chinese edible mushrooms, Boletus calopus and Suillus bovinus, on cytochrome P450 (CYP) 1A2, 2C9, 2D6, and 3A4, the main drug-metabolizing enzymes. Three pulvinic acid derivatives, atromentic acid (1), variegatic acid (2), and xerocomic acid (3), isolated from Boletus calopus and Suillus bovinus, revealed nonspecific inhibitory effects on all four CYPs. Using these compounds, the maximum IC50 values obtained with CYP3A4 in vitro were atromentic acid (1), 65.1±3.9 μM; variegatic acid (2), 2.2±0.1 μM; and xerocomic acid (3), 2.4±0.1 μM. Variegatic acid (2) and xerocomic acid (3) were effective inhibitors, comparable to cimetidine, dicoumarol, erythromycin, safrole, and uniconazole. Variegatic acid (2) and xerocomic acid (3) efficiently reduced ferryl myoglobin in CYPs. Reduction of ferryl heme to ferric heme is likely the mechanism of the nonspecific inhibitory effects of these compounds on CYPs.
- 社団法人 日本農芸化学会の論文
著者
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Abe Naoki
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Yoshikawa Kunie
Department Of Microbiology National Institute Of Hygienic Sciences
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Onose Jun-Ichi
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
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HUANG Yu-Ting
Department of Biotechnology, Chia-Nan University of Pharmacy and Science
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Onose Jun-ichi
Department Of Nutritional Science Faculty Of Applied Bio-science Tokyo University Of Agriculture
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